• Publications
  • Influence
Ghrelin stimulates gastric acid secretion and motility in rats.
Ghrelin, a novel growth-hormone-releasing peptide, was discovered in rat and human stomach tissues. However, its physiological and pharmacological actions in the gastric function remain to beExpand
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Gastrointestinal sounds and migrating motor complex in fasted humans
Objective:We investigated the relationships among gastrointestinal sounds, gastrointestinal manometric findings, and small intestinal transit time in healthy fasted humans.Methods:GastrointestinalExpand
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Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog.
The gastrointestinal motor stimulating activity of erythromycin (EM) was studied in conscious dogs. It was found that a 20-min intravenous infusion of EM lactobionate at a dose of 50-100 microgramsExpand
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Motilin and Clinical Application
  • Z. Itoh
  • Biology, Medicine
  • Peptides
  • 31 December 1997
Motilin is a regulatory polypeptide of 22 amino acid residues and orginates in motilin cells scattered in the duodenal epithelium of most mammals and chickens. Motilin is released into the generalExpand
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AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs.
The effects of AS-4370 [4-amino-5-chloro-2-ethoxy-N-(4-(4-fluorobenzyl)-2 morpholinyl)methyl)benzamide citrate] on gastrointestinal (GI) motor activity were compared with those of cisapride andExpand
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Involvement of 5-hydroxytryptamine 3 receptors in regulation of interdigestive gastric contractions by motilin in the dog.
The effects of IV injection of 5-hydroxytryptamine 3 receptor antagonists (BRL 43694 and GR38032F) on gastrointestinal contractile activity were studied in dogs with vagally denervated fundic pouchExpand
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Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs
Simultaneous measurement of plasma motilin concentration and gastrointestinal contractile activity was made in 12 healthy dogs. Plasma motilin concentration was measured by radioimmunoassay andExpand
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Diurnal changes in gastric motor activity in conscious dogs
Twenty-four-hour changes in gastric motor activity were recorded in 4 healthy adult dogs in the conscious state by means of extraluminal force transducers. Three major different gastric motorExpand
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Acotiamide Hydrochloride (Z-338), a New Selective Acetylcholinesterase Inhibitor, Enhances Gastric Motility without Prolonging QT Interval in Dogs: Comparison with Cisapride, Itopride, and Mosapride
Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4-carboxamide monohydrochloride trihydrate, Z-338) has been reported toExpand
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  • PDF
Inhibition of phase III activity by acid in canine stomach
Very few phase III activity of the interdigestive migrating contractions (phase III) occurs in the stomach of fasted duodenal ulcer patients. But the mechanism is not well understood. In this study,Expand
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