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Z 338

Known as: ACOTIAMIDE, Z-338 
A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Acotiamide HydrochlorideBenzamidesThiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Stability-indicating assay method for acotiamide: Separation, identification and characterization of its hydroxylated and hydrolytic degradation products along with a process-related impurity by…
RATIONALE The presence of impurities and degradation products will affect the pharmacokinetic, pharmacodynamic properties and… 
2016
2016
Quantitation of acotiamide in rat plasma by UHPLC-Q-TOF-MS: method development, validation and application to pharmacokinetics.
A novel, sensitive and selective ultra-high-performance liquid chromatography-electrospray ionization mass spectrometry method… 
Review
2014
Review
2014
Evaluation of acotiamide for the treatment of functional dyspepsia
Introduction: The treatment for functional dyspepsia (FD) (indigestion) remains unsatisfactory. Acotiamide is a new prokinetic… 
2012
2012
Targeting cathepsins: a new glimmer of hope for pancreatic cancer therapy?
Recent whole-genome sequencing efforts have facilitated the detailed characterisation of the human degradome consisting of almost… 
Review
2011
Review
2011
Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia
Introduction: Functional dyspepsia (FD) is a highly prevalent condition with a major impact on quality of life and high socio… 
2008
2008
1053 A Novel Acetylcholine Esterase Inhibitor Acotiamide Hydrochloride (YM443) in Functional Dyspepsia: Efficacy in a Randomized, Double-Blind, Placebo-Controlled Dose Ranging Trial
2008
2008
963 Influence of PPI Run-in, pH Monitoring and Nutrient Tolerance On Efficacy Outcomes of Acotiamide Hydrochloride (YM443), a Novel Acetylcholine Esterase Inhibitor, in Functional Dyspepsia
2002
2002
An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z‐338
To study the mechanisms involved in the action of Z‐338, a newly synthesized gastroprokinetic agent, experiments were performed… 
2000
2000
Z-338, a newly synthetized carboxyamide derivative, stimulates gastric motility through enhancing the excitatory neurotransmission.
We studied the effects of Z-338, a newly synthesized carboxyamide derivative, on autonomic neuroeffector transmission in the… 
1994
1994
Determination of acenocoumarol in human plasma by capillary gas chromatography with mass-selective detection.
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