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Z 338

Known as: ACOTIAMIDE, Z-338 
A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet… Expand
National Institutes of Health

Papers overview

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2016
2016
BackgroundAcotiamide is widely used to improve symptoms in patients with functional dyspepsia (FD) in multiple large-scale… Expand
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Review
2013
Review
2013
Dyspepsia refers to a heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms… Expand
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Highly Cited
2012
Highly Cited
2012
OBJECTIVE To determine the efficacy of acotiamide, an acetylcholinesterase inhibitor, in patients with functional dyspepsia (FD… Expand
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Review
2011
Review
2011
INTRODUCTION Functional dyspepsia (FD) is a highly prevalent condition with a major impact on quality of life and high socio… Expand
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2011
2011
Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Acotiamide is a selective acetylcholinesterase inhibitor and enhances the actions of cholinergic neurons localized in… Expand
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Review
2010
Review
2010
Acotiamide hydrochloride is a novel upper gastrointestinal (GI) motility modulator and stress regulator currently being developed… Expand
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Highly Cited
2009
Highly Cited
2009
Impaired gastric accommodation, hypersensitivity to distension and delayed gastric emptying are major pathophysiological… Expand
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2008
2008
Acotiamide hydrochloride (Z-338) is a member of new class prokinetic agents currently being developed for the treatment of… Expand
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Review
2008
Review
2008
  • Jan Tack
  • Current opinion in pharmacology
  • 2008
Gastrointestinal prokinetics are a heterogeneous class of drugs that stimulate smooth muscle contractions to enhance gastric… Expand
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