Acetylserotonin N-Methyltransferase

Known as: Oxyindol O Methyltransferase, Hydroxyindole O-Methyltransferase, O-Methyltransferase, Acetylserotonin 
An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine… (More)
National Institutes of Health

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9 relations
ACETYLSEROTONIN METHYLTRANSFERASE, X-CHROMOSOMAL GENEASMT geneIn BloodProcess of secretion
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant… (More)
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Highly Cited
2007
Highly Cited
2007
Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls
The catechol-O-methyltransferase (COMT) Val158Met polymorphism is hypothesized to affect executive function in patient and… (More)
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Highly Cited
2007
Highly Cited
2007
Gene-gene interaction associated with neural reward sensitivity.
Reward processing depends on dopaminergic neurotransmission and is modulated by factors affecting dopamine (DA) reuptake and… (More)
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Highly Cited
2005
Highly Cited
2005
Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.
Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. A… (More)
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Highly Cited
2005
Highly Cited
2005
Catechol-O-Methyltransferase (COMT) Genotypes and Working Memory: Associations with Differing Cognitive Operations
BACKGROUND Catechol-O-methyltransferase (COMT) is a strong candidate gene for schizophrenia and cognitive functions disrupted in… (More)
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Highly Cited
2005
Highly Cited
2005
Effect of catechol-O-methyltransferase val158met genotype on attentional control.
The cingulate cortex is richly innervated by dopaminergic projections and plays a critical role in attentional control (AC… (More)
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Highly Cited
2004
Highly Cited
2004
Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex.
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences… (More)
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Highly Cited
1999
Highly Cited
1999
The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.
Among the family of steroidal molecules, only estrogens have the capability of preventing neuronal cell death caused by increased… (More)
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Highly Cited
1998
Highly Cited
1998
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior.
Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines… (More)
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Highly Cited
1972
Highly Cited
1972
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat.
The role of vision in neuroendocrine regulation is well-known1, 2, but few data are available on specific visual pathways… (More)
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