Acetyl-CoA C-Acyltransferase

Known as: CoA Acyltransferase, Acetyl, Acyltransferase, Acetyl CoA, Thiolase, 3-Oxoacyl CoA 
Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is… (More)
National Institutes of Health

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3-oxoadipyl-coenzyme A thiolaseDeficiency of acetyl-CoA acetyltransferaseMedium Chain 3-Ketoacyl-CoA Thiolase Deficiency
ACAA1 geneACAA2 geneAcetyl-CoA C-AcetyltransferaseIn Blood
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2
www.sciencemag.org (this information is current as of August 7, 2008 ): The following resources related to this article are… (More)
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Highly Cited
2007
Highly Cited
2007
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
Hypothalamic fatty acid metabolism has recently been implicated in the controls of food intake and energy homeostasis. We report… (More)
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Highly Cited
2006
Highly Cited
2006
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads to hepatic insulin resistance… (More)
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Highly Cited
2002
Highly Cited
2002
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.
Acetyl-coenzyme A (CoA) synthetase (Acs) is an enzyme central to metabolism in prokaryotes and eukaryotes. Acs synthesizes acetyl… (More)
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Highly Cited
2002
Highly Cited
2002
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.
UNLABELLED Changes in the concentration of malonyl-CoA in many tissues have been related to alterations in the activity of acetyl… (More)
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Highly Cited
2001
Highly Cited
2001
Role of AMP-activated protein kinase in mechanism of metformin action.
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose… (More)
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Highly Cited
2001
Highly Cited
2001
Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.
Using peptide sequences derived from bovine cardiac acetyl-CoA synthetase (AceCS), we isolated and characterized cDNAs for a… (More)
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Review
1999
Review
1999
Malonyl-CoA, fuel sensing, and insulin resistance.
Malonyl-CoA is an allosteric inhibitor of carnitine palmitoyltransferase (CPT) I, the enzyme that controls the transfer of long… (More)
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Highly Cited
1993
Highly Cited
1993
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.
The role of acetyl-coenzyme A carboxylase (ACC) in regulating fatty acid oxidation was investigated in isolated fatty acid… (More)
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Highly Cited
1989
Highly Cited
1989
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.
1. We have purified the AMP-activated protein kinase 4800-fold from rat liver. The acetyl-CoA carboxylase kinase and 3-hydroxy-3… (More)
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