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Acetyl-CoA C-Acetyltransferase

Known as: Acetyl CoA C Acetyltransferase, thiolase, Thiolase, Acetoacetyl CoA 
An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred… Expand
National Institutes of Health

Related topics

Related topics

14 relations
ACAT1 geneAcetyl-CoA C-AcyltransferaseIn BloodProcess of secretion
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Narrower (4)

ACAT1 protein, humanCytosolic acetoacetyl-CoA thiolase deficiencyHMG CoA lyase deficiencyHydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency

Broader (1)

Acyltransferase

Papers overview

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Review
2019
Review
2019
Coupling Krebs cycle metabolites to signalling in immunity and cancer
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new… Expand
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Review
2018
Review
2018
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.
Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules… Expand
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Highly Cited
2006
Highly Cited
2006
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD+-dependent deacetylases that modulate gene silencing, aging… Expand
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Highly Cited
2002
Highly Cited
2002
Evidence Supporting a Role of Jasmonic Acid in Arabidopsis Leaf Senescence1
In this work, the role of jasmonic acid (JA) in leaf senescence is examined. Exogenous application of JA caused premature… Expand
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Highly Cited
2000
Highly Cited
2000
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Trimetazidine is a clinically effective antianginal agent that has no negative inotropic or vasodilator properties. Although it… Expand
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Review
1997
Review
1997
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.
The intracellular concentration of free unbound acyl-CoA esters is tightly controlled by feedback inhibition of the acyl-CoA… Expand
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Highly Cited
1995
Highly Cited
1995
High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of…
We determined whether high fatty acid oxidation rates during aerobic reperfusion of ischemic hearts could be explained by a… Expand
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Highly Cited
1991
Highly Cited
1991
A novel, cleavable peroxisomal targeting signal at the amino‐terminus of the rat 3‐ketoacyl‐CoA thiolase.
Several peroxisomal proteins do not contain the previously identified tripeptide peroxisomal targeting signal (PTS) at their… Expand
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Highly Cited
1991
Highly Cited
1991
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.
We have examined the onset and duration of the inhibitory effect of an intravenous infusion of lipid/heparin on total body… Expand
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Highly Cited
1969
Highly Cited
1969
Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.
  • F. Fonnum
  • The Biochemical journal
  • 1969
    • Corpus ID: 2484855
1. The methods for the assay of choline acetyltransferase were based on the reaction between labelled acetyl-CoA and unlabelled… Expand
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