Acetyl-CoA C-Acetyltransferase

Known as: Acetyl CoA C Acetyltransferase, thiolase, Thiolase, Acetoacetyl CoA 
An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred… (More)
National Institutes of Health

Related topics

Related topics

14 relations
ACAT1 geneAcetyl-CoA C-AcyltransferaseIn BloodProcess of secretion
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Narrower (4)

ACAT1 protein, humanCytosolic acetoacetyl-CoA thiolase deficiencyHMG CoA lyase deficiencyHydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency

Broader (1)

Acyltransferase

Papers overview

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Highly Cited
2008
Highly Cited
2008
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
SIRT1, a histone/protein deacetylase, and AMP-activated protein kinase (AMPK) are key enzymes responsible for longevity and… (More)
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Highly Cited
2006
Highly Cited
2006
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.
Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD(+)-dependent deacetylases that modulate gene silencing, aging… (More)
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Highly Cited
2006
Highly Cited
2006
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.
Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are… (More)
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Review
2004
Review
2004
The rocky roots of the acetyl-CoA pathway.
Geologists have suggested that life might have emerged at hydrothermal vents, chemists have shown that metal sulphides such as… (More)
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Highly Cited
2000
Highly Cited
2000
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Trimetazidine is a clinically effective antianginal agent that has no negative inotropic or vasodilator properties. Although it… (More)
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Highly Cited
1998
Highly Cited
1998
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha).
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the steroid/nuclear receptor superfamily and mediates… (More)
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Highly Cited
1995
Highly Cited
1995
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of…
We determined whether high fatty acid oxidation rates during aerobic reperfusion of ischemic hearts could be explained by a… (More)
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1995
1995
Characterization of an acetyl-CoA C-acetyltransferase (thiolase) gene from Clostridium acetobutylicum ATCC 824.
Thiolase (Thl) is an important enzyme at the junction in the pathway leading to the production of either acids (acetate or… (More)
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Highly Cited
1991
Highly Cited
1991
A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase.
Several peroxisomal proteins do not contain the previously identified tripeptide peroxisomal targeting signal (PTS) at their… (More)
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Highly Cited
1969
Highly Cited
1969
Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.
1. The methods for the assay of choline acetyltransferase were based on the reaction between labelled acetyl-CoA and unlabelled… (More)
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