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A ligand-binding pocket in the dengue virus envelope glycoprotein
Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E fromExpand
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Structure of the dengue virus envelope protein after membrane fusion
Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome. The conformational changeExpand
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X-ray structure of a protein-conducting channel
A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. WeExpand
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SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.
Mutations affecting spliceosomal proteins are the most common mutations in patients with myelodysplastic syndromes (MDS), but their role in MDS pathogenesis has not been delineated. Here we reportExpand
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Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein
ABSTRACT Dengue virus is an emerging global health threat. The major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. Antibodies that bind but fail to neutralizeExpand
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Atomic model of the papillomavirus capsid
Papillomaviruses propagate in differentiating skin cells, and certain types are responsible for the onset of cervical cancer. We have combined image reconstructions from electron cryomicroscopyExpand
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Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5
Most organisms rely on innate immune receptors to recognize conserved molecular structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5, detect viral double-strandedExpand
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MDA5 cooperatively forms dimers and ATP‐sensitive filaments upon binding double‐stranded RNA
Melanoma differentiation‐associated gene‐5 (MDA5) detects viral double‐stranded RNA in the cytoplasm. RNA binding induces MDA5 to activate the signalling adaptor MAVS through interactions between theExpand
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Crystal Structure of West Nile Virus Envelope Glycoprotein Reveals Viral Surface Epitopes
ABSTRACT West Nile virus, a member of the Flavivirus genus, causes fever that can progress to life-threatening encephalitis. The major envelope glycoprotein, E, of these viruses mediates viralExpand
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