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AZD7451

Known as: TRK Inhibitor AZD7451, Tropomyosin Receptor Kinase Inhibitor AZD7451 
A tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK… 
National Institutes of Health

Related topics

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5 relations

Broader (2)

2-AminopurinePyrazoles
AZ12607092Receptor Tyrosine Kinase Inhibitionanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro…
2014
2014
Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro.
Advances in the molecular segmentation of lung cancer has raised the possibility that neurotrophic tyrosine kinase receptor (NTRK… 
2014
2014
ET-30A PHASE I TRIAL OF AZD7451, A TROPOMYOSIN-RECEPTOR KINASE (TRK) INHIBITOR, FOR ADULTS WITH RECURRENT GLIOBLASTOMA MULTIFORME (GBM)
BACKGROUND: We have shown that inhibition of TrkA both genetically and pharmacologically results in profound inhibition of glioma… 
2013
2013
A novel uHPLC-MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma.
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