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AZD7451

Known as: TRK Inhibitor AZD7451, Tropomyosin Receptor Kinase Inhibitor AZD7451 
A tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

2-AminopurinePyrazoles
AZ12607092Receptor Tyrosine Kinase Inhibitionanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A sensitive and rapid ultra high-performance liquid chromatography with tandem mass spectrometric assay for the simultaneous quantitation of cyclophosphamide and the 4-hydroxycyclophosphamide…
2016
2016
Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro…
2014
2014
Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro.
Advances in the molecular segmentation of lung cancer has raised the possibility that neurotrophic tyrosine kinase receptor (NTRK… 
2014
2014
ET-30A PHASE I TRIAL OF AZD7451, A TROPOMYOSIN-RECEPTOR KINASE (TRK) INHIBITOR, FOR ADULTS WITH RECURRENT GLIOBLASTOMA MULTIFORME (GBM)
BACKGROUND: We have shown that inhibition of TrkA both genetically and pharmacologically results in profound inhibition of glioma… 
Highly Cited
2013
Highly Cited
2013
TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior
Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for… 
2013
2013
A novel uHPLC-MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma.
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