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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Significant phenotypic and genotypic differences are demonstrated between primary human tumor-derived TSCs and their matched glioma cell lines, suggesting that TSC's may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors. Expand
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain.
It is demonstrated that SCF directly activates brain microvascular endothelial cells in vitro and induces a potent angiogenic response in vivo and the SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain. Expand
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma.
This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma. Expand
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma.
- T. Kreisl, L. Kim, +10 authors H. Fine
- Journal of clinical oncology : official journal…
- 10 February 2009
It is concluded that single-agent bevacizumab has significant biologic and antiglioma activity in patients with recurrent glioblastoma. Expand
SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma.
It is demonstrated that stage-specific embryonic antigen 1(SSEA-1/LeX)+ GBM cells fulfill the functional criteria for TSC/TIC, since S SEA-1+ cells are highly tumorigenic in vivo, unlike SSEA- 1- cells. Expand
Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research
- S. Madhavan, J. Zenklusen, Y. Kotliarov, Himanso Sahni, H. Fine, K. Buetow
- Computer Science, Medicine
- Molecular Cancer Research
- 1 February 2009
Repository of Molecular Brain Neoplasia Data (Rembrandt), a cancer clinical genomics database and a Web-based data mining and analysis platform aimed at facilitating discovery by connecting the dots between clinical information and genomic characterization data is presented. Expand
Cellular-telephone use and brain tumors.
Data do not support the hypothesis that the recent use of hand-held cellular telephones causes brain tumors, but they are not sufficient to evaluate the risks among long-term, heavy users and for potentially long induction periods. Expand
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
It is demonstrated that both bone morphogenetic protein (BMP)-mediated and ciliary neurotrophic factor (CNTF)-mediated Jak/STAT-dependent astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs. Expand
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
The results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma. Expand
Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases.
- E. Alexander, T. Moriarty, +5 authors J. Loeffler
- Journal of the National Cancer Institute
- 4 January 1995
Results of this retrospective analysis show that radiosurgery is an effective, minimally invasive outpatient treatment option for small intracranial metastases and is also effective in treating patients with surgically inaccessible lesions, with multiple lesions, or with tumor types that are resistant to conventional treatment. Expand