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AXIN1 protein

Known as: Protein Phosphatase 1, Regulatory Subunit 49, Axin 1, hAxin 
Product of the Axin1 Gene. Triggers degradation of beta-catenin and helps establish dorsal-ventral patterning during embryogenesis.
National Institutes of Health

Related topics

Related topics

10 relations
ALK PathwayAXIN1 geneAXIN1 wt AlleleBeta-Catenin Accumulation Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
The Roles of Intrinsic Disorder in Orchestrating the Wnt-Pathway
Abstract The canonical Wnt-pathway plays a number of crucial roles in the development of organism. Malfunctions of this pathway… 
Highly Cited
2008
Highly Cited
2008
The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin
β-Catenin-mediated Wnt signaling is essential in embryonic development and in adult tissues. Recent studies have demonstrated… 
Highly Cited
2006
Highly Cited
2006
Hexachlorophene Inhibits Wnt/β-Catenin Pathway by Promoting Siah-Mediated β-Catenin Degradation
Aberrant activation of Wnt/β-catenin signaling and subsequent up-regulation of β-catenin response transcription (CRT) is a… 
2006
2006
Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor
Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor 
2004
2004
A blockade in Wnt signaling is activated following the differentiation of F9 teratocarcinoma cells.
2004
2004
Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin*
Adenomatous polyposis coli (APC) protein and Axin form a complex that mediates the down-regulation of β-catenin, a key effector… 
Highly Cited
2001
Highly Cited
2001
The role of maternal axin in patterning the Xenopus embryo.
Regulation of the stability of beta catenin protein is a critical role of Wnt signaling cascades. In early Xenopus development… 
Highly Cited
2000
Highly Cited
2000
Domains of axin and disheveled required for interaction and function in wnt signaling.
Disheveled blocks the degradation of beta-catenin in response to Wnt signal by interacting with the scaffolding protein, Axin. To… 
2000
2000
Tumor-associated Apc mutations in Mlh1−/−Apc1638N mice reveal a mutational signature of Mlh1 deficiency
Apc1638N mice, which are heterozygous for a germline mutation in Apc, typically develop three to five spontaneous intestinal… 
1999
1999
Axin prevents Wnt-3a-induced accumulation of beta-catenin.
When Axin, a negative regulator of the Wnt signaling pathway, was expressed in COS cells, it coeluted with glycogen synthase… 
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