AXIN1 protein

Known as: Protein Phosphatase 1, Regulatory Subunit 49, Axin 1, hAxin 
Product of the Axin1 Gene. Triggers degradation of beta-catenin and helps establish dorsal-ventral patterning during embryogenesis.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key regulated step of the Wnt pathway. It… (More)
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Review
2007
Review
2007
The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most… (More)
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Highly Cited
2005
Highly Cited
2005
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the… (More)
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Review
2004
Review
2004
Three closely related forms of glycogen synthase kinase 3 (GSK-3alpha, GSK-3beta and GSK-3beta2) have a major role in Wnt and… (More)
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Highly Cited
2001
Highly Cited
2001
Medulloblastoma (MB) represents the most frequent malignant brain tumor in children. Most MBs appear sporadically; however, their… (More)
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Highly Cited
2001
Highly Cited
2001
The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, forms a Wnt-regulated signaling… (More)
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Highly Cited
2001
Highly Cited
2001
Zebrafish embryos homozygous for the masterblind (mbl) mutation exhibit a striking phenotype in which the eyes and telencephalon… (More)
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Highly Cited
2001
Highly Cited
2001
The inhibition of GSK3 is required for the stimulation of glycogen and protein synthesis by insulin and the specification of cell… (More)
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Highly Cited
1999
Highly Cited
1999
beta-catenin plays an essential role in the Wingless/Wnt signaling cascade and is a component of the cadherin cell adhesion… (More)
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Highly Cited
1999
Highly Cited
1999
b-Catenin plays a dual role in the cell: one in linking the cytoplasmic side of cadherin-mediated cell–cell contacts to the actin… (More)
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