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ARID1A protein, human

Known as: AT rich interactive domain 1A (SWI- like), human, SWI-Like Protein, BRG1-Associated Factor, 250-kD 
AT-rich interactive domain-containing protein 1A (2285 aa, ~242 kDa) is encoded by the human ARID1A gene. This protein plays a role in chromatin… 
National Institutes of Health

Related topics

Related topics

11 relations
ARID DomainARID1A geneChromatin Remodeling Complex and Coactivator PathwayGenes, Regulator

Broader (3)

ARID1A wt AlleleNuclear ProteinsTRANSCRIPTION FACTOR

Papers overview

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Highly Cited
2020
Highly Cited
2020
ARID1A alterations function as a biomarker for longer progression-free survival after anti-PD-1/PD-L1 immunotherapy
Background Several cancer types harbor alterations in the gene encoding AT-Rich Interactive Domain-containing protein 1A (ARID1A… 
Highly Cited
2018
Highly Cited
2018
Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer
Highly Cited
2017
Highly Cited
2017
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.
Highly Cited
2015
Highly Cited
2015
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.
UNLABELLED ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a… 
Highly Cited
2014
Highly Cited
2014
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signaling
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a… 
Review
2014
Review
2014
The emerging roles of ARID1A in tumor suppression
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of cancers, especially in those arising from… 
Highly Cited
2014
Highly Cited
2014
Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition
ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial… 
Highly Cited
2013
Highly Cited
2013
Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer
The switch/sucrose non-fermentable (SWI/SNF) subunit ARID1A (AT-rich interactive domain 1A gene) has been recently postulated as… 
Highly Cited
2012
Highly Cited
2012
Loss of ARID1A Expression Is an Early Molecular Event in Tumor Progression From Ovarian Endometriotic Cyst to Clear Cell and Endometrioid Carcinoma
Objectives ARID1A is a recently identified tumor suppressor participating in chromatin remodeling. Somatic inactivating mutations… 
Highly Cited
2002
Highly Cited
2002
Largest Subunits of the Human SWI/SNF Chromatin-remodeling Complex Promote Transcriptional Activation by Steroid Hormone Receptors*
The mammalian SWI/SNF-related complexes facilitate gene transcription by remodeling chromatin using the energy of ATP hydrolysis… 
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