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The role of DNA mismatch repair in platinum drug resistance.
Loss of DNA mismatch repair occurs in many types of tumors. The effect of the loss of DNA mismatch repair activity on sensitivity to cisplatin and a panel of analogues was tested using two pairs ofExpand
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The role of DNA mismatch repair in drug resistance.
Loss of DNA mismatch repair (MMR) has been observed in a variety of human cancers. In addition to predisposing to oncogenesis, loss of MMR activity is of concern with respect to the use ofExpand
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Loss of DNA mismatch repair in acquired resistance to cisplatin.
Selection of cells for resistance to cisplatin, a well-recognized mutagen, could result in mutations in genes involved in DNA mismatch repair and thereby to resistance to DNA-alkylating agents.Expand
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No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting.
OBJECTIVE About 70% of epithelial ovarian cancer patients (EOC) are diagnosed at advanced stage with a five-year survival rate of only 30%. Whilst CA125 detects peritoneally-spread disease, it hasExpand
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Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.
  • S. Aebi, D. Fink, +4 authors S. Howell
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 1 October 1997
Loss of DNA mismatch repair is a common finding in many types of sporadic human cancers as well as in tumors arising in patients with hereditary nonpolyposis colon cancer. The effect of the loss ofExpand
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The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage
Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclearExpand
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Mismatch repair proficiency and in vitro response to 5-fluorouracil.
BACKGROUND & AIMS The DNA mismatch repair (MMR) system recognizes certain DNA adducts caused by alkylation damage in addition to its role in recognizing and directing repair of interstrand nucleotideExpand
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Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement.
PURPOSE To evaluate magnetic resonance (MR) imaging with ultrasmall superparamagnetic iron oxide (USPIO) enhancement for preoperative axillary lymph node staging in patients with breast cancer byExpand
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Analysis of MLH1 and MSH2 expression in ovarian cancer before and after platinum drug-based chemotherapy.
Preclinical studies have demonstrated a relationship between DNA mismatch repair (MMR) status and sensitivity to cisplatin and carboplatin. MMR-deficient cells are resistant to both drugs, andExpand
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ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and Endometriosis-Associated Ovarian Carcinomas
Endometriosis is a common gynecological disease affecting 6%–10% of women of reproductive age and is characterized by the presence of endometrial-like tissue in localizations outside of the uterineExpand
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