Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

  title={Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition},
  author={Eleftherios Pierre Samartzis and Katrin Gutsche and Konstantin Johannes Dedes and Daniel Fink and Manuel Stucki and Patrick Imesch},
ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial, and breast carcinomas. They commonly result in loss of ARID1A-protein expression and frequently co-occur with PI3K/AKT-pathway activating mechanisms. The aim of this study was to test the hypothesis as to whether PI3K/AKT-pathway activation is a critical mechanism in ARID1A-mutated tumors and if consequently ARID1A-deficient tumors show increased sensitivity to… CONTINUE READING
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