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APLP1 protein, human

Known as: Amyloid Precursor-Like Protein, APLP protein, human, amyloid beta (A4) precursor-like protein 1, human 
Amyloid-like protein 1 (650 aa, ~72 kDa) is encoded by the human APLP1 gene. This protein plays a role in the mediation of postsynaptic signaling.
National Institutes of Health

Related topics

Related topics

10 relations
APLP1 geneCerebral cortexG Protein-Coupled Receptor SignalingIntegral Membrane Proteins

Broader (1)

Amyloid beta-Protein Precursor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2
The molecular association between APP and its mammalian homologs has hardly been explored. In systematically addressing this… 
Highly Cited
2006
Highly Cited
2006
Polymerization efficacy of simplified adhesive systems studied by NMR and MRI techniques.
Highly Cited
2005
Highly Cited
2005
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
Highly Cited
2005
Highly Cited
2005
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
Amyloid beta-peptide (Abeta), which plays a central role in Alzheimer's disease, is generated by presenilin-dependent gamma… 
Highly Cited
2004
Highly Cited
2004
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n…
Amyloid precursor protein (APP) processing is of major interest in Alzheimer's disease research, since sequential cleavages by… 
Highly Cited
2003
Highly Cited
2003
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Regulated intramembrane proteolysis (RIP) of the amyloid precursor protein (APP) produces amyloid beta-protein (Abeta), the… 
Highly Cited
2001
Highly Cited
2001
Proteome studies of human cerebrospinal fluid and brain tissue using a preparative two‐dimensional electophoresis approach prior to mass spectrometry
A preparative proteomic approach, involving liquid phase isoelectric focusing (IEF) in combination with one‐dimensional… 
Highly Cited
2000
Highly Cited
2000
Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease
Highly Cited
1996
Highly Cited
1996
Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat
Recent reports suggest a relationship between traumatic brain injury and the precocious development of neurodegenerative cascades… 
Highly Cited
1994
Highly Cited
1994
Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.
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