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APLP1 gene

Known as: AMYLOID BETA A4 PRECURSOR-LIKE PROTEIN 1, AMYLOID PRECURSOR-LIKE PROTEIN 1, amyloid beta precursor like protein 1 
This gene plays a role in synaptic signaling.
National Institutes of Health

Related topics

Related topics

4 relations
APLP1 protein, humanG Protein-Coupled Receptor SignalingSignal Transductionnervous system development

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2
The molecular association between APP and its mammalian homologs has hardly been explored. In systematically addressing this… 
Highly Cited
2008
Highly Cited
2008
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese‐exposed non‐human primates
Chronic manganese (Mn) exposure produces a neurological syndrome with psychiatric, cognitive, and parkinsonian features. Gene… 
Highly Cited
2006
Highly Cited
2006
Effects of endogenous β‐amyloid overproduction on tau phosphorylation in cell culture
Alzheimer's disease is characterized by β‐amyloid (Aβ) overproduction and tau hyperphosphorylation. Recent studies have shown… 
Highly Cited
2004
Highly Cited
2004
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.
Site-specific proteolysis of the amyloid-beta precursor protein (APP) by BACE 1 and gamma-secretase, a central event in Alzheimer… 
Highly Cited
2003
Highly Cited
2003
blue cheese Mutations Define a Novel, Conserved Gene Involved in Progressive Neural Degeneration
A common feature of many human neurodegenerative diseases is the accumulation of insoluble ubiquitin-containing protein… 
2003
2003
Amyloid (cid:1) Protein Precursor Is Phosphorylated by JNK-1 Independent of, yet Facilitated by, JNK-Interacting Protein (JIP)-1*
Alzheimer’s disease (AD) is genetically linked to the processing of amyloid (cid:1) protein precursor (A (cid:1) PP). Aside from… 
Highly Cited
2000
Highly Cited
2000
Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members
The amyloid precursor protein (APP) involved in Alzheimer's disease is a member of a larger gene family including amyloid… 
Highly Cited
1997
Highly Cited
1997
Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice
1994
1994
APP gene family: unique age-associated changes in splicing of Alzheimer's βA4-amyloid protein precursor
The betaA4-amyloid protein precursor (APP) is a transmembrane glycoprotein that is the source of the characteristic betaA4… 
Highly Cited
1993
Highly Cited
1993
The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.
We have recently isolated a cDNA from a mouse brain library that encodes a protein whose predicted amino acid sequence is 42… 
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