Skip to search formSkip to main contentSkip to account menu

ALOX5 gene

Known as: ARACHIDONATE 5-LIPOXYGENASE, 5-LOX, ALOX5 
This gene plays a role in inflammation.
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (1)

ALOX5 wt Allele
Arachidonate 5-LipoxygenaseLipid MetabolismOxidation-Reductioninflammatory response

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.
A drug discovery program in search of novel 5-lipoxygenase activating protein (FLAP) inhibitors focused on driving a reduction in… 
2007
2007
ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study
The aim of this study was to explore the role of variants of the gene encoding arachidonate 5-lipoxygenase-activating protein… 
Review
2005
Review
2005
Genes contributing to risk for common forms of stroke.
2005
2005
Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.
2003
2003
Amino Acid Differences in the Deduced 5-Lipoxygenase Sequence of CAST Atherosclerosis-Resistance Mice Confer Impaired Activity When Introduced Into the Human Ortholog
Objectives—The mouse strain CON6, which was generated by breeding athero-resistant CAST mice into an athero-susceptible B6… 
Highly Cited
2001
Highly Cited
2001
Structural Basis for Lipoxygenase Specificity
Mammalian lipoxygenases constitute a heterogeneous family of lipid-peroxidizing enzymes, and the various isoforms are categorized… 
Highly Cited
2000
Highly Cited
2000
Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats
Review
2000
Review
2000
Genetic variations in the 5-lipoxygenase core promoter. Description and functional implications.
The regulation of 5-lipoxygenase (5-LO) activity occurs at multiple steps and is quite complex; each of the regulatory steps has… 
Review
1992
Review
1992
15-Lipoxygenase products as leukotriene antagonists: therapeutic potential in glomerulonephritis.
In the first few hours following immune complex deposition and complement-mediated neutrophil (PMN) infiltration, glomerular… 
1988
1988
Activation of the Arachidonate 5‐Lipoxygenase Pathway in the Canine Basilar Artery After Experimental Subarachnoidal Hemorrhage
Abstract: Severe cerebral vasospasm as confirmed by an‐giography was induced in dogs by injection of autologous blood into the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)