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Arachidonate 5-Lipoxygenase

Known as: 5-Lipoxygenase, Arachidonic Acid, ALOX5, EC 1.13.11.34 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to… Expand
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a… Expand
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Highly Cited
2004
Highly Cited
2004
We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12–13. A four-marker single-nucleotide… Expand
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Review
2001
Review
2001
  • C. Funk
  • Science
  • 2001
  • Corpus ID: 12564549
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that… Expand
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Highly Cited
2001
Highly Cited
2001
Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas lipoxins (LXs) have unique anti-inflammatory… Expand
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Review
2000
Review
2000
Many antiinflammatory pharmaceutical products inhibit the production of certain eicosanoids and cytokines and it is here that… Expand
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Review
1990
Review
1990
THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 , 2 three to four decades before it was… Expand
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Highly Cited
1990
Highly Cited
1990
We report here that the bacterial lipopolysaccharide endotoxin induces human blood monocytes in a time- and dose-dependent manner… Expand
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Highly Cited
1990
Highly Cited
1990
LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… Expand
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Review
1987
Review
1987
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… Expand
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Highly Cited
1980
Highly Cited
1980
Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or by lipoxygenases to… Expand
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