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Arachidonate 5-Lipoxygenase

Known as: 5-Lipoxygenase, Arachidonic Acid, ALOX5, EC 1.13.11.34 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to… 
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Signalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids control important cellular processes… 
Highly Cited
2004
Highly Cited
2004
Review
2001
Review
2001
  • C. Funk
  • Science
  • 2001
  • Corpus ID: 12564549
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that… 
Highly Cited
2001
Highly Cited
2001
Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas lipoxins (LXs) have unique anti-inflammatory… 
Review
2000
Review
2000
Many antiinflammatory pharmaceutical products inhibit the production of certain eicosanoids and cytokines and it is here that… 
Review
1990
Review
1990
THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 , 2 three to four decades before it was… 
Review
1987
Review
1987
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… 
Highly Cited
1980
Highly Cited
1980
Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or by lipoxygenases to…