Arachidonate 5-Lipoxygenase

Known as: 5-Lipoxygenase, Arachidonic Acid, ALOX5, EC 1.13.11.34 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory lipid… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n-6 fatty acid) by the enzyme… (More)
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Highly Cited
2004
Highly Cited
2004
We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12–13. A four-marker single-nucleotide… (More)
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Highly Cited
2003
Highly Cited
2003
Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte… (More)
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Review
2001
Review
2001
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that… (More)
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Highly Cited
1999
Highly Cited
1999
Interest in the health-promoting effects of virgin olive oil, an important part of the 'Mediterranean diet', prompted us to… (More)
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Highly Cited
1993
Highly Cited
1993
The intracellular distribution of the enzyme 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) in resting and… (More)
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Highly Cited
1990
Highly Cited
1990
LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… (More)
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Review
1987
Review
1987
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… (More)
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1983
1983
Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the… (More)
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