Global strategy for asthma management and prevention: GINA executive summary
- E. Bateman, S. Hurd, H. Zar
- MedicineEuropean Respiratory Journal
- 1 January 2008
It is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained, and the Global Initiative for Asthma recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions.
The biology of nitrogen oxides in the airways.
- B. Gaston, J. Drazen, J. Loscalzo, J. Stamler
- Biology, MedicineAmerican Journal of Respiratory and Critical Care…
- 1 February 1994
Nitrogen oxides (NOx), regarded in the past primarily as toxic air pollutants, have recently been shown to be bioactive species formed endogenously in the human lung, and have opened a new horizon of therapeutic possibilities for pulmonary medicine.
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
The purpose of this review is to highlight the molecular characterization of the ALX receptor and provide an overview of theALX-LXA4 axis responsible for anti-inflammatory and proresolving signals in vivo.
Statistics in medicine--reporting of subgroup analyses in clinical trials.
- Rui Wang, S. Lagakos, J. Ware, David J. Hunter, J. Drazen
- MathematicsNew England Journal of Medicine
- 22 November 2007
The analysis of subgroups is often used as a way to glean additional information from data sets. The strengths and weaknesses of this approach and new Journal policies concerning the reporting of…
International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
- C. Brink, S. Dahlén, T. Yokomizo
- Chemistry, BiologyPharmacological Reviews
- 1 March 2003
The aim of this review is to provide the molecular evidence as well as the properties and significance of the leukotriene and lipoxin receptors, which has lead to the present nomenclature.
Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet
- S. Finotto, M. Neurath, L. Glimcher
- Biology, MedicineScience
- 11 January 2002
T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.
A summary of the new GINA strategy: a roadmap to asthma control
- H. Reddel, E. Bateman, J. FitzGerald
- MedicineEuropean Respiratory Journal
- 23 July 2015
The changes include a revised asthma definition, tools for assessing symptom control and risk factors for adverse outcomes, and updated strategies for adaptation and implementation of GINA recommendations.
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma.
- J. Bousquet, E. Mantzouranis, T. Zuberbier
- MedicineJournal of Allergy and Clinical Immunology
- 1 November 2010
Treatment of asthma with drugs modifying the leukotriene pathway.
- J. Drazen, E. Israel, P. O'Byrne
- MedicineNew England Journal of Medicine
- 1 October 1999
On the mechanism of mucosal folding in normal and asthmatic airways.
- B. Wiggs, C. Hrousis, J. Drazen, R. Kamm
- BiologyJournal of applied physiology
- 1 December 1997
A finite-element analysis of a two-layer composite model for an airway is used to investigate the factors that determine the mucosal folding pattern and how it is altered as a result of changes in the thickness or stiffness of the different layers that comprise the airway wall.
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