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AKR1C2 gene

Known as: DD, HAKRD, dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III 
This gene plays a role in the metabolism of steroid hormones.
National Institutes of Health

Related topics

Related topics

7 relations
AKR1C2 protein, humanAKR1C3 wt AlleleAKR1E2 geneOxidation-Reduction

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AKR1C2 wt Allele

Papers overview

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2012
2012
Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes.
Adipogenesis and lipid storage in human adipose tissue are inhibited by androgens such as DHT. Inactivation of DHT to 3α-diol is… 
2010
2010
Chicken ileal bile-acid-binding protein: a promising target of investigation to understand binding co-operativity across the protein family.
Protein-bile acid interactions are crucial microscopic events at the basis of both physiological and pathological biochemical… 
2008
2008
Binding and interactions of L-BABP to lipid membranes studied by molecular dynamic simulations.
2007
2007
Identification and functional characterization of the bile acid transport proteins in non‐mammalian ileum and mammalian liver
It has been proposed that intracellular carrier proteins mediate active transport of the bile acids within hepatocytes and… 
2006
2006
Expression of dihydrodiol dehydrogenase and resistance to chemotherapy and radiotherapy in adenocarcinoma cells of lung.
BACKGROUND The cytoplasmic enzyme dihydrodiol dehydrogenase (DDH) plays an important role in the detoxification process. Recently… 
2005
2005
Localization and altered expression of AKR1C family members in human ovarian tissues.
2003
2003
FXRE can function as an LXRE in the promoter of human ileal bile acid‐binding protein (I‐BABP) gene
Highly Cited
2002
Highly Cited
2002
Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines.
In this report, we compared kinetic constants and products in the reduction of the neurosteroids, 3alpha,5alpha… 
1996
1996
Effect of bile on the intestinal bile‐acid binding protein (I‐BABP) expression. In vitro and in vivo studies
1991
1991
Identification of the 14 kDa bile acid transport protein of rat ileal cytosol as gastrotropin.
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