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Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker
Background— Although we know much about the molecular makeup of the sinus node (SN) in small mammals, little is known about it in humans. The aims of the present study were to investigate theExpand
Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy.
The poor selective toxicity of chemotherapeutic anticancer drugs leads to dose-limiting side effects that compromise clinical outcome. Solid tumors recruit new blood vessels to support tumor growth,Expand
PDZ‐mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
The PDZ target motifs located in the C‐terminal end of many receptors and ion channels mediate protein–protein interactions by binding to specific PDZ‐containing proteins. These interactions areExpand
The GLT‐1 and GLAST Glutamate Transporters Are Expressed on Morphologically Distinct Astrocytes and Regulated by Neuronal Activity in Primary Hippocampal Cocultures
Abstract: The GLT‐1 and GLAST astroglial transporters are the glutamate transporters mainly involved in maintaining physiological extracellular glutamate concentrations. Defects in neurotransmitterExpand
Protection of Sinorhizobium against Host Cysteine-Rich Antimicrobial Peptides Is Critical for Symbiosis
A bacterial membrane protein, BacA, protects Sinorhizobium meliloti against the antimicrobial activity of host peptides, enabling the peptides to induce bacterial persistence rather than bacterialExpand
Spontaneous Formation of L-Isoaspartate and Gain of Function in Fibronectin*
Isoaspartate formation in extracellular matrix proteins, by aspartate isomerization or asparagine deamidation, is generally viewed as a degradation reaction occurring in vivo during tissue aging. ForExpand
Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience.
By acting through retinal nicotinic acetylcholine receptors (nAChRs), acetylcholine plays an important role in the development of both the retina and central visual pathways. Ligand binding andExpand
Syntaxin 1A is delivered to the apical and basolateral domains of epithelial cells: the role of munc-18 proteins.
SNARE (Soluble N-ethyl-maleimide sensitive factor Attachment protein Receptor) proteins assemble in tight core complexes, which promote fusion of carrier vesicles with target compartments. Members ofExpand
Cancer immunotherapy based on killing of Salmonella-infected tumor cells.
A major obstacle for the development of effective immunotherapy is the ability of tumors to escape the immune system. The possibility to kill tumor cells because they are recognized as infectedExpand
Microglia induce myelin basic protein‐specific T cell anergy or T cell activation, according to their state of activation
Microglial cells are non‐professional antigen‐presenting cells (APC) the function of which is still controversial. Here, we studied the function of microglia derived from H‐2u mice. We show thatExpand