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Pathophysiology of human visceral obesity: an update.
In clinical practice, measuring waist circumference in addition to the body mass index could be helpful for the identification and management of a subgroup of overweight or obese patients at high cardiometabolic risk.
Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men?
It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad and at high risk for CAD.
What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?
The results support the existence of a subgroup of obese but metabolically normal postmenopausal women who display high levels of insulin sensitivity despite having a high accumulation of body fat.
Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study.
These results represent the first prospective evidence suggesting that the presence of small, dense LDL particles may be associated with an increased risk of subsequently developing IHD in men and suggest that the risk attributed to small LDL particle may be partly independent of the concomitant variation in plasma lipoprotein-lipid concentrations.
Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
Adiposity was a significant predictor of plasma CRP in postmenopausal women on a cross-sectional basis and caloric restriction–induced weight loss decreased plasmaCRP levels, suggesting weight loss may represent an important intervention to reduce CRP levels.
Why might South Asians be so susceptible to central obesity and its atherogenic consequences? The adipose tissue overflow hypothesis.
- A. Sniderman, R. Bhopal, D. Prabhakaran, N. Sarrafzadegan, A. Tchernof
- Medicine, BiologyInternational journal of epidemiology
- 1 February 2007
It is hypotheses that as obesity develops, South Asians exhaust the storage capacity of their superficial subcutaneous adipose tissue compartment before whites do and that is why they develop the metabolic complications of upper body obesity at lower absolute masses of adiposes tissue than white people.
A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men.
The identification of a consistent and rather uniform pattern of differentially expressed genes between the two fat depots using multiple array replicates generated new perspectives for future research on regional differences in adipose tissue biology.
Prevention of gestational diabetes mellitus: a review of studies on weight management
- A. Morisset, A. St-Yves, Johanne Veillette, S. Weisnagel, A. Tchernof, J. Robitaille
- MedicineDiabetes/metabolism research and reviews
- 1 January 2010
It is concluded that weight management through nutritional prevention strategies could be successful in reducing the risk of GDM, independent of pre‐pregnancy BMI.
Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women
It is confirmed that LEP and ADIPOQ epigenetic profiles are associated with obesity and similar correlations were observed between LDL-C and LEP bloodDNA methylation levels suggesting a common regulatory pathway of DNA methylation in both adipose tissues and blood.
Regional Differences in Adipose Tissue Metabolism in Women
Compared with adipocytes from the omental fat compartment, subcutaneous adipocytes are larger, have higher LPL activity, and are more lipolytic on an absolute basis, which may reflect a higher fat storage capacity in this depot in women.