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AG 2034

Known as: AG2034 
National Institutes of Health

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2 relations

Broader (2)

GlutamatesPyrimidines

Papers overview

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2010
2010
Emax model and interaction index for assessing drug interaction in combination studies.
Applying the Emax model in a Lowe additivity model context, we analyze data from a combination study of trimetrexate (TMQ) and… 
2009
2009
Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence
4‐[2‐(2‐Amino‐4‐oxo‐4,6,7,8‐tetrahydro‐3H‐pyrimidino[5,4,6][1,4]thiazin‐6‐yl)‐(S)‐ethyl]‐2,5‐thienoylamino‐l‐glutamic acid… 
2009
2009
Membrane Transport Properties and Biological Activity of Stereo-isomers of Glycinamide Ribonucleotide Formyltransferase (GARFT) Inhibitors AG2032 and AG2034
2008
2008
The depletion of cellular ATP by AG2034 mediates cell death or cytostasis in a hypoxanthine-dependent manner in human prostate cancer cells
Purpose4-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4] thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-l-glutamic… 
2006
2006
The Critical Role of Polyglutamylation Reductase and Inhibitors of Other Folate-requiring Enzymes : Synergy between Inhibitors of Dihydrofolate in Vitro Super Updated
The combined action among polyglutamylatable and nonpolyglutamylatable antifolates, directed against dihydrofolate reducÃ-ase… 
Highly Cited
2004
Highly Cited
2004
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
SummaryThe glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5… 
2003
2003
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against…
In order to examine the intracellular locus of the folic acid (PteGlu)-enhanced synergies of trimetrexate (TMQ) plus the… 
2001
2001
Keyword index
§-casein, P2–97 -amylase, P1–102 -amylase inhibitor, P1–102 1,4-diazabicyclo[2.2.2]octane, YSF–10 11-beta-hydroxysteroid… 
Review
1999
Review
1999
Clinical pharmacokinetics of antitumor antifolates.
Antifolate drugs, as a class, have broad-spectrum activity against both hematologic and solid human malignancies. The… 
1997
1997
An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint
Purpose: We studied the effects of purine depletion on the cell cycle using a specific inhibitor of de novo purine biosynthesis… 
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