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ACVRL1 wt Allele

Known as: ACVRL1, ALK-1, Activin A Receptor, Type II-Like Kinase 1 wt Allele 
Human ACVRL1 wild-type allele is located within 12q11-q14 and is approximately 14 kb in length. This allele, which encodes serine/threonine-protein… 
National Institutes of Health

Related topics

Related topics

11 relations
12q11-q14ACVRL1 protein, humanHereditary hemorrhagic telangiectasiaHomo sapiens

Broader (1)

ACVRL1 gene

Papers overview

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Review
2011
Review
2011
ALK1 as an emerging target for antiangiogenic therapy of cancer.
Members of the TGF-β family act on many, if not all, cell types within the body, producing diverse and complex cellular outcomes… 
Review
2010
Review
2010
Signaling by members of the TGF-beta family in vascular morphogenesis and disease.
Highly Cited
2008
Highly Cited
2008
ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2.
ALK1 belongs to the type I receptor family for transforming growth factor-beta family ligands. Heterozygous ALK1 mutations cause… 
Highly Cited
2008
Highly Cited
2008
ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes
Introduction: TGF‐β is a multifunctional regulator of chondrocyte proliferation, differentiation, and extracellular matrix… 
Highly Cited
2007
Highly Cited
2007
Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers
Summary.  Background: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by epistaxis, mucocutaneous… 
Highly Cited
2003
Highly Cited
2003
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
Background: Mutations of the transforming growth factor β (TGFβ) receptor components ENDOGLIN and ALK-1 cause the autosomal… 
Highly Cited
2002
Highly Cited
2002
Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor‐β in human umbilical vein endothelial cells
Transforming growth factor‐β (TGF‐β) plays a crucial role in vascular development and homeostasis by regulating many… 
Highly Cited
1999
Highly Cited
1999
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.
The biological effects of type I serine/threonine kinase receptors and Smad proteins were examined using an adenovirus-based… 
Highly Cited
1998
Highly Cited
1998
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.
Transforming growth factor beta (TGF-beta) is an extracellular ligand that binds to a heterodimeric receptor, initiating signals… 
Highly Cited
1993
Highly Cited
1993
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like… 
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