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Keratinocyte‐specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
To elucidate the biological role of Stat3 in the skin, conditional gene targeting using the Cre‐loxP system was performed as germline Stat3 ablation leads to embryonic lethality. K5‐Cre;Stat3flox/−Expand
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Targeted disruption of LIG‐1 gene results in psoriasiform epidermal hyperplasia 1
The gene encoding a transmembrane glycoprotein LIG‐1, of which the extracellular region was organized with the leucine‐rich repeats and immunoglobulin‐like domains, was disrupted in mice by geneExpand
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Mesenchymal–epithelial interactions in the skin
We investigated whether or not the topographic regulation of melanocyte differentiation is determined by mesenchymal–epithelial interactions via fibroblast-derived factors. The melanocyte density inExpand
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Induction of T‐cell‐mediated skin disease specific for antigen transgenically expressed in keratinocytes
Transgenic mice were generated to establish an animal model for T‐cell‐mediated autoimmune skin disease. A membrane‐bound form of OVA (mOVA) was specifically expressed under the control of thekeratinExpand
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Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth
We attempted establishing an in vitro coculture system by using human dermal papilla cells (DPCs) from androgenetic alopecia (AGA) and keratinocytes (KCs) to explore the role of androgens in hairExpand
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Cutaneous Wound Healing: An Update
Our understanding of wound‐healing mechanisms has progressed over the past decade. Wound healing is traditionally divided into three phases—the inflammatory phase, the proliferation phase, and theExpand
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Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.
Since heparin-binding epidermal growth factor (HB-EGF) is a member of the EGF family and binds to EGF receptor, we tested recombinant HB-EGF for its ability to stimulate human keratinocyteExpand
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Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor.
Effect of hepatocyte growth factor (HGF) on normal human epidermal keratinocytes cultured under conditions of low Ca2+ (0.1 mM, growth-promoting condition) and physiological Ca2+ (1.8 mM,Expand
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Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal human keratinocytes cultured in serum-free medium.
The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the growth of normal human keratinocytes cultured in serum-free medium was investigated. 1,25(OH)2D3 inhibited the cell growth at 10(-7) M byExpand
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