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A-740003

Known as: A740003 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Subjected to Mechanical Strain
Inflammatory responses play a key role in many neural pathologies, with localized signaling from non-immune cells making critical… 
2015
2015
P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages
2015
2015
E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role
Ischemia/reperfusion (I/R) elicits renin release from cardiac mast cells (MC), thus activating a local renin‐angiotensin system… 
2015
2015
Activation of P2X7 receptors in the midbrain periaqueductal gray of rats facilitates morphine tolerance
2015
2015
p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons
Background We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of… 
2012
2012
P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line
Gliomas are the most lethal tumors of central nervous system. ATP is an important signaling molecule in CNS and it is a selective… 
2011
2011
Award Number: W81XWH-10-1-0813 TITLE: Development of a Small Molecule P2X7R Antagonist as a Treatment for Acute SCI
Spinal cord injury (SCI) is often complicated by secondary ischemic injury as a result of the innate inflammatory response to tr… 
2008
2008
Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.
Review
2007
Review
2007
P2X currents in peritoneal macrophages of wild type and P2X4 -/- mice.
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