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Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
The NLRP3–ASC inflammasome, which is an important sensor of innate immunity and intensively explored for its role in health and disease, presents as an interesting therapeutic approach to target three crucial pathogenetic processes in AD, including prion-like seeding of Tau pathology, Aβ pathology and neuroinflammation.
Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor.
Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo
Time‐lapse analysis of the pattern of cortical invasion by microglial cells in mouse embryos at the onset of neuronal cell migration shows that embryonic microglia are highly dynamic cells.
Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons.
It is demonstrated that hDPSCs are capable of neuronal commitment following neurosphere formation, characterized by distinct morphological and electrophysiological properties of functional neuronal cells.
PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes.
Although PDZ-based interactions are dispensable for the biosynthetic targeting to the proper membrane domain, the PDZ network ensures that the membrane proteins are efficiently retained at the cell surface.
Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo
Data indicate that activation of the fetal microglial cells is not likely to be responsible for the inflammation induced deficits in the offspring in this model.
Sustained synchronized neuronal network activity in a human astrocyte co-culture system
An in vitro co-culture model of hiPSC-derived cortical neurons and human primary astrocytes that recapitulates neuronal network synchronization and connectivity within three to four weeks after final plating is established and is amenable to high throughput screening for lead discovery and drug optimization for neurological diseases.
Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel.
- H. Gijsen, Didier Berthelot, M. Zaja, B. Brône, I. Geuens, M. Mercken
- Chemistry, BiologyJournal of medicinal chemistry
- 31 August 2010
The use of ligands such as 6 and 32 as pharmacological tools may contribute to the basic knowledge of the TRPA1 channel and advance the development ofTRPA1 antagonists as potential treatment for conditions involving TRPA 1 activation, including asthma and pain.
Microglia: Brain cells on the move
Identification of Protein Networks Involved in the Disease Course of Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis
Quantitative analysis of differentially expressed brainstem proteins in an animal model of MS is a first step to identify disease-associated proteins and networks that warrant further research to study their actual contribution to disease pathology.