• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
CATSPER Channel-Mediated Ca2+ Entry into Mouse Sperm Triggers a Tail-to-Head Propagation1
TLDR
It is shown that a Ca2+ influx in the principal piece through CATSPER channels can not only initiate hyperactivated motility, but can also trigger a tail-to-head Ca2- propagation that leads to an increase in [NADH] and may regulate ATP homeostasis. Expand
Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.
TLDR
The results indicate that vATPase deficiency in PS1 loss-of-function states causes lysosomal/autophagy deficits and contributes to abnormal cellular Ca(2+) homeostasis, thus linking two AD-related pathogenic processes through a common molecular mechanism. Expand
A release mechanism for stored ATP in ocular ciliary epithelial cells.
TLDR
Both layers of the ciliary epithelium store and release ATP, and purines likely modulate aqueous humor flow by paracrine and/or autocrine mechanisms within the two cell layers of this epithelia. Expand
Release of ATP by a human retinal pigment epithelial cell line: potential for autocrine stimulation through subretinal space
  • C. Mitchell
  • Biology, Medicine
  • The Journal of physiology
  • 1 July 2001
TLDR
The results suggest that growth factors, pyrimidines and changes in tonicity could trigger ATP release into subretinal space and may be capable of autocrine stimulation of ATP receptors, while conversion to adenosine by ecto‐enzymes could alter phagocytosis. Expand
Neurons respond directly to mechanical deformation with pannexin‐mediated ATP release and autostimulation of P2X7 receptors
TLDR
Stretch‐dependent release of ATP through neuronal pannexins, combined with the autostimulation of the P2X7 receptors, provides a new pathway by which neuronal activity and health can be altered by mechanical strain independently of glial activity. Expand
Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder
TLDR
The data indicate a role for pannexin‐mediated luminal ATP release in both the physiological and pathophysiological control of micturition and suggest that urothelialpannexin may be a viable target for the treatment of overactive bladder disorders. Expand
A3 adenosine receptors regulate Cl-channels of nonpigmented ciliary epithelial cells.
TLDR
It is concluded that human HCE cells and rabbit ciliary processes possess A3 receptors and that adenosine can activate Cl- channels in NPE cells by stimulating these A3receptors. Expand
Identification of the A3 adenosine receptor in rat retinal ganglion cells.
TLDR
Retinal ganglion cells express A3 adenosine receptor mRNA and Stimulation of this receptor can reduce the Ca2+ overload following excessive activation of P2X7 receptors. Expand
Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells.
TLDR
Short-term stimulation of the P2X(7) receptor can raise Ca(2+) in rat retinal ganglion cells, whereas sustained stimulation of this receptor can kill them. Expand
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