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International Union of Pharmacology. XIII. Classification of histamine receptors.
TLDR
The classification of histamine receptors has to date been based on rigorous classical pharmacological analysis, and as yet, the classification of the three histamines receptors that have been defined by this process have not been added to because of lack of evidence.
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Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1
TLDR
The results suggest that NO∗ synthesis in both macrophages and endothelial cells depends on an NADPH‐utilizing flavoprotein, and DPI and its analogs are likely to prove useful in analyzing the physiologic and pathophysiologic roles of NO·.
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Nitric oxide synthase in macula densa regulates glomerular capillary pressure.
TLDR
It is concluded that nitric oxide synthase in macula densa cells is activated by tubular-fluid reabsorption and mediates a vasodilating component to the tubuloglomerular feedback response.
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Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras(*)
TLDR
P21ras is essential for NO-induced downstream signaling, such as NF-κB activation, and that endogenous NO can activate p21ras in the same cell, and it is suggested that NO activates p21ra by an action which mimics that of guanine nucleotide exchange factors.
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Identification of arginine as a precursor of endothelium-derived relaxing factor.
TLDR
Observations strongly suggest that, in the intact guinea pig pulmonary artery, EDRF originates from enzymatic action on the guanido nitrogen(s) of an endogenous pool of arginine, strikingly similar to the origin of reactive nitrogen intermediates in activated macrophages.
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Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
L-arginine-dependent synthesis of nitrite (NO2-) and nitrate (NO3-) by macrophages correlates with and is required for their execution of nonspecific cytotoxicity toward some tumor cells and…
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Histamine and cardiac arrhythmias.
TLDR
The ability to record transmembrane action potenrial(s) (TAP) from single cells has permitted the study of electrophysiological mechanisms underlying histamine-induced arrhythmias.
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Nitric oxide in the regulation of blood flow and arterial pressure.
TLDR
This review focuses on the systemic vascular phar­ macology of NO, rather than on its important roles in the pulmonary and uteroplacental circulations, citing selected investigations that bear on its role in several aspects of hemodynamic regulation.
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Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion.
TLDR
Mast cell-derived renin is pivotal for activating a cardiac renin-angiotensin system leading to excessive norepinephrine release in ischemia/reperfusion and may be a useful therapeutic target for hyperadrenergic dysfunctions, such as arrhythmias, sudden cardiac death, myocardial ischemIA, and congestive heart failure.
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NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic…
TLDR
NMA, a selective inhibitor of NO synthesis from L-arginine, was investigated on sympathetic renal nerve activity, blood pressure, and heart rate in the anesthetized rat and baroreceptor deafferentation markedly altered these responses to NMA.
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