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MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its… Expand Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging… Expand Systemic administration of a Toll-like receptor 7 (TLR7) agonist is effective to in suppressing Th2 derived inflammation, however… Expand The blockage of transcription elongation by RNA polymerase II (RNAPII) at DNA lesions on the transcribed strand is a serious… Expand Cells are continuously exposed to oxidative species, which cause several types of oxidative DNA lesions. Repair of some of these… Expand Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damages that are thought to lead to deleterious… Expand Werner syndrome (WS) is a premature aging disorder where the affected individuals appear much older than their chronological age… Expand BACKGROUND
Guanine residues in the genome are vulnerable to attack by free radicals and reactive oxygen species. A major lesion… Expand Two oligodeoxyribonucleotides, d-CTTCTTTTTTATTTT, I(A), and d-ATTATTTTTTATTTT, II(A), where C is 5-methylcytosine and A is 8… Expand The structure of the synthetic deoxydodecamer d(CGCGAATT(O8A)GCG)2 (O8A = 8-oxoadenine) has been determined by single-crystal X… Expand