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8-oxoadenine

 
National Institutes of Health

Papers overview

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2013
2013
We report the discovery of novel series of highly potent TLR7 agonists based on 8-oxoadenines, 1 and 2 by introducing and… Expand
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Highly Cited
2011
Highly Cited
2011
Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging… Expand
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2010
2010
Systemic administration of a Toll-like receptor 7 (TLR7) agonist is effective to in suppressing Th2 derived inflammation, however… Expand
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2007
2007
The blockage of transcription elongation by RNA polymerase II (RNAPII) at DNA lesions on the transcribed strand is a serious… Expand
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2005
2005
Clustered DNA lesions, possibly induced by ionizing radiation, constitute a trial for repair processes. Indeed, recent studies… Expand
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2003
2003
Cells are continuously exposed to oxidative species, which cause several types of oxidative DNA lesions. Repair of some of these… Expand
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2001
2001
Werner syndrome (WS) is a premature aging disorder where the affected individuals appear much older than their chronological age… Expand
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1999
1999
Epidemiological evidence suggests that certain paternal exposures to metals may increase the risk of cancer in the progeny. This… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Guanine residues in the genome are vulnerable to attack by free radicals and reactive oxygen species. A major lesion… Expand
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1992
1992
Two oligodeoxyribonucleotides, d-CTTCTTTTTTATTTT, I(A), and d-ATTATTTTTTATTTT, II(A), where C is 5-methylcytosine and A is 8… Expand
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