8-oxoadenine

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
012319922018

Papers overview

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2013
2013
We report the discovery of novel series of highly potent TLR7 agonists based on 8-oxoadenines, 1 and 2 by introducing and… (More)
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2010
2010
Systemic administration of a Toll-like receptor 7 (TLR7) agonist is effective to in suppressing Th2 derived inflammation, however… (More)
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2007
2007
The blockage of transcription elongation by RNA polymerase II (RNAPII) at DNA lesions on the transcribed strand is a serious… (More)
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2005
2005
Clustered DNA lesions, possibly induced by ionizing radiation, constitute a trial for repair processes. Indeed, recent studies… (More)
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2003
2003
Cells are continuously exposed to oxidative species, which cause several types of oxidative DNA lesions. Repair of some of these… (More)
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2000
2000
Individuals with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many characteristics of… (More)
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1998
1998
Free-radical-induced DNA damage by ionizing radiation leads to a number of oxidized purines, of which 7H-8-oxoguanine (8OG) and… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Guanine residues in the genome are vulnerable to attack by free radicals and reactive oxygen species. A major lesion… (More)
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1992
1992
Two oligodeoxyribonucleotides, d-CTTCTTTTTTATTTT, I(A), and d-ATTATTTTTTATTTT, II(A), where C is 5-methylcytosine and A is 8… (More)
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1992
1992
The structure of the synthetic deoxydodecamer d(CGCGAATT(O8A)GCG)2 (O8A = 8-oxoadenine) has been determined by single-crystal X… (More)
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