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8-oxoadenine

National Institutes of Health

Papers overview

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2016
2016
MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its… Expand
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Highly Cited
2011
Highly Cited
2011
Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging… Expand
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2010
2010
Systemic administration of a Toll-like receptor 7 (TLR7) agonist is effective to in suppressing Th2 derived inflammation, however… Expand
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Highly Cited
2007
Highly Cited
2007
The blockage of transcription elongation by RNA polymerase II (RNAPII) at DNA lesions on the transcribed strand is a serious… Expand
2003
2003
Cells are continuously exposed to oxidative species, which cause several types of oxidative DNA lesions. Repair of some of these… Expand
Highly Cited
2001
Highly Cited
2001
Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damages that are thought to lead to deleterious… Expand
Highly Cited
2001
Highly Cited
2001
Werner syndrome (WS) is a premature aging disorder where the affected individuals appear much older than their chronological age… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Guanine residues in the genome are vulnerable to attack by free radicals and reactive oxygen species. A major lesion… Expand
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1992
1992
Two oligodeoxyribonucleotides, d-CTTCTTTTTTATTTT, I(A), and d-ATTATTTTTTATTTT, II(A), where C is 5-methylcytosine and A is 8… Expand
1992
1992
The structure of the synthetic deoxydodecamer d(CGCGAATT(O8A)GCG)2 (O8A = 8-oxoadenine) has been determined by single-crystal X… Expand