Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex.

@article{Konvalinov2015DiverseEO,
  title={Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex.},
  author={Helena Konvalinov{\'a} and Zuzana Dvoř{\'a}kov{\'a} and Daniel Ren{\vc}iuk and Kl{\'a}ra Bedn{\'a}řov{\'a} and Iva Kejnovsk{\'a} and Luk{\'a}{\vs} Trant{\'i}rek and M. Vorlickova and Janos Sagi},
  journal={Biochimie},
  year={2015},
  volume={118},
  pages={
          15-25
        }
}
Various base lesions continuously form in cellular nucleic acids and the unrepaired lesions are promutagenic and procarcinogenic. Though natural base lesions have been extensively studied in double-stranded DNA models, these studies are only less than a decade old for non-canonical DNA models, such as quadruplexes. Here we present a report on the effects of three frequently occurring natural lesions that can form in the TTA loops on the structure of the human telomere quadruplex d[AG3(TTAG3)3… CONTINUE READING
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