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Marine-derived fungi: a chemically and biologically diverse group of microorganisms.

A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally,…
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WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

TLDR
It is proposed that WLS binds Wnts in part through a lipid-binding domain, and that vacuolar acidification is required to release palmitoylated WNT3A from WLS in secretory vesicles, possibly to facilitate transfer of Wnt3A to a soluble carrier protein.
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Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges

Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we…
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Biomedical Potential of Marine Natural Products

TLDR
The intent of this chapter is to look back at the evolution of biomedically oriented natural product studies of marine organisms, to chronicle the key developments, discoveries, and advances in the level of sophistication that have fueled further interest in this field, and to look forward at the future biomedical potential of marine natural products.
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Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.

TLDR
Two new isomalabaricane triterpenes have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines and showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor cells.
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Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis.

  • H. HeW. Ding G. Carter
  • Chemistry, Medicine
    Journal of the American Chemical Society
  • 11 May 2001
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Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya

TLDR
The structure determination of the new compounds are reported and preliminary evidence for the ability of this class of metabolites to inhibit the function of mammalian topoisomerase 119 and to inhibits the growth of human ovarian tumor in an athymic mouse model is reported.
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Diterpenes from Dolabella californica.

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Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp

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Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa.

Four new depsipeptides, mirabamides E-H (1-4), and the known depsipeptide mirabamide C (5) have been isolated from the sponge Stelletta clavosa, collected from the Torres Strait. The planar…
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