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Marine-derived fungi: a chemically and biologically diverse group of microorganisms.
A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally,… Expand
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
Wnt proteins are secreted post-translationally modified proteins that signal locally to regulate development and proliferation. The production of bioactive Wnts requires a number of dedicated factors… Expand
Biomedical Potential of Marine Natural Products
Marine natural products, the secondary or nonprimary metabolites produced by organisms that live in the sea, have received increasing attention from chemists and pharmacologists during the last two… Expand
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
- D. Tasdemir, G. C. Mangalindan, +7 authors C. Ireland
- Chemistry, Medicine
- Journal of natural products
- 26 January 2002
Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D… Expand
Distinct Pathways Generate Peptides from Defective Ribosomal Products for CD8+ T Cell Immunosurveillance
- B. Dolan, Lily Li, C. Veltri, C. Ireland, J. Bennink, J. Yewdell
- Biology, Medicine
- The Journal of Immunology
- 15 February 2011
To understand better the endogenous sources of MHC class I peptide ligands, we generated an antigenic reporter protein whose degradation is rapidly and reversibly controlled with Shield-1, a… Expand
Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis.
Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
- S. Pimentel-Elardo, S. Kozytska, T. Bugni, C. Ireland, H. Moll, U. Hentschel
- Biology, Medicine
- Marine drugs
- 23 February 2010
Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we… Expand
Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp
Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity.
Antineoplastic cyclic peptides from the marine tunicate Lissoclinum patella