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7-bromoindirubin-3'-oxime

Known as: 7BIO cpd 
 
National Institutes of Health

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2 relations

Broader (2)

IndolesOximes

Papers overview

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2019
2019
Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) and 7-bromoindirubin-3'-oxime (7BIO).
Indirubins E804 (indirubin-3'-(2,3 dihydroxypropyl)-oximether) and 7BIO (7-Bromoindirubin-3'-oxime) are synthetic derivatives of… Expand
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2017
2017
Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice
Indirubins are natural occurring alkaloids extracted from indigo dye-containing plants. Indirubins could inhibit various kinases… Expand
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2015
2015
Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3′-oxime (7BIO)
BackgroundThe indirubin derivative 7-bromoindirubin-3′-oxime (7BIO) has already shown anticancer properties by causing cell death… Expand
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2015
2015
An evaluation of indirubin analogues as phosphorylase kinase inhibitors.
Phosphorylase kinase (PhK) has been linked with a number of conditions such as glycogen storage diseases, psoriasis, type 2… Expand
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2012
2012
Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells.
Indirubin derivatives gained interest in recent years for their anticancer and antimetastatic properties. The objective of the… Expand
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Highly Cited
2009
Highly Cited
2009
Cutting edge: Necrosis activates the NLRP3 inflammasome.
Cells undergoing necrosis release endogenous danger signals that possess proinflammatory potential. In this study we show that… Expand
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2009
2009
Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.
The bis-indole alkaloid indirubin and its analogues bear a very interesting natural pharmacophore. They are recognized mainly as… Expand
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2008
2008
7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death.
The new 7-bromoindirubin-3'-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date… Expand
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2007
2007
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.
A variation of the bromine substitution from 6- to 7-position converts the glycogen synthase kinase-3alpha/beta-(GSK-3-alpha/beta… Expand
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2006
2006
7-Bromoindirubin-3′-oxime induces caspase-independent cell death
Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3… Expand
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