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7-bromoindirubin-3'-oxime

Known as: 7BIO cpd 
 
National Institutes of Health

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2 relations

Broader (2)

IndolesOximes

Papers overview

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2019
2019
Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) and 7-bromoindirubin-3'-oxime (7BIO).
Indirubins E804 (indirubin-3'-(2,3 dihydroxypropyl)-oximether) and 7BIO (7-Bromoindirubin-3'-oxime) are synthetic derivatives of… Expand
2017
2017
Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice
Indirubins are natural occurring alkaloids extracted from indigo dye-containing plants. Indirubins could inhibit various kinases… Expand
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2015
2015
Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3′-oxime (7BIO)
BackgroundThe indirubin derivative 7-bromoindirubin-3′-oxime (7BIO) has already shown anticancer properties by causing cell death… Expand
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2015
2015
An evaluation of indirubin analogues as phosphorylase kinase inhibitors.
Phosphorylase kinase (PhK) has been linked with a number of conditions such as glycogen storage diseases, psoriasis, type 2… Expand
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2012
2012
Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells.
Indirubin derivatives gained interest in recent years for their anticancer and antimetastatic properties. The objective of the… Expand
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2009
2009
Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.
The bis-indole alkaloid indirubin and its analogues bear a very interesting natural pharmacophore. They are recognized mainly as… Expand
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Highly Cited
2009
Highly Cited
2009
Cutting Edge: Necrosis Activates the NLRP3 Inflammasome1
Cells undergoing necrosis release endogenous danger signals that possess proinflammatory potential. In this study we show that… Expand
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2008
2008
7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death.
The new 7-bromoindirubin-3'-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date… Expand
Highly Cited
2007
Highly Cited
2007
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.
A variation of the bromine substitution from 6- to 7-position converts the glycogen synthase kinase-3alpha/beta-(GSK-3-alpha/beta… Expand
Highly Cited
2006
Highly Cited
2006
7-Bromoindirubin-3′-oxime induces caspase-independent cell death
Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3… Expand
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