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Drp1 Mediates Caspase-Independent Type III Cell Death in Normal and Leukemic Cells
ABSTRACT Ligation of CD47 triggers caspase-independent programmed cell death (PCD) in normal and leukemic cells. Here, we characterize the morphological and biochemical features of this type of deathExpand
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Defective Neuromuscular Junction Organization and Postnatal Myogenesis in Mice With Severe Spinal Muscular Atrophy
A detailed pathologic analysis was performed on Smn−/−;SMN2+/+ mice as a mouse model for human type I spinal muscular atrophy (SMA). We provide new data concerning changes in the spinal cord,Expand
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  • Open Access
Neuregulin‐1 is concentrated in the postsynaptic subsurface cistern of C‐bouton inputs to α‐motoneurons and altered during motoneuron diseases
C boutons are large, cholinergic, synaptic terminals that arise from local interneurons and specifically contact spinal α‐motoneurons (MNs). C boutons characteristically display a postsynapticExpand
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Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord
Several studies have reported the neuroprotective effects of lithium (Li) suggesting its potential in the treatment of neurological disorders, among of them amyotrophic lateral sclerosis (ALS).Expand
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Effects of excitatory amino acids on neuromuscular development in the chick embryo
To investigate the presumptive role of excitatory amino acids (EAAs) in the regulation of normally occurring motoneuron (MN) death, chick embryos were treated with the glutamate receptor antagonistsExpand
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Opposing Effects of Excitatory Amino Acids on Chick Embryo Spinal Cord Motoneurons: Excitotoxic Degeneration or Prevention of Programmed Cell Death
Acute administration of a single dose of NMDA on embryonic day (E) 7 or later induces a marked excitotoxic injury in the chick spinal cord, including massive necrotic motoneuron (MN) death. When theExpand
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  • Open Access
In Vivo Analysis of Schwann Cell Programmed Cell Death in the Embryonic Chick: Regulation by Axons and Glial Growth Factor
The present study uses the embryonic chick to examine in vivo the mechanisms and regulation of Schwann cell programmed cell death (PCD) in spinal and cranial peripheral nerves. Schwann cells areExpand
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  • Open Access
Survival and death of mature avian motoneurons in organotypic slice culture: Trophic requirements for survival and different types of degeneration
We have developed an organotypic culture technique that uses slices of chick embryo spinal cord, in which trophic requirements for long‐term survival of mature motoneurons (MNs) were studied. SlicesExpand
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Rescue of developing spinal motoneurons from programmed cell death by the GABAA agonist muscimol acts by blockade of neuromuscular activity and increased intramuscular nerve branching
Blockade of neuromuscular activity in the chick embryo during the period of programmed cell death of motoneurons results in a complete rescue of these cells. Understanding the cellular mechanismsExpand
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Mechanisms involved in spinal cord central synapse loss in a mouse model of spinal muscular atrophy.
Motoneuron (MN) cell death is the histopathologic hallmark of spinal muscular atrophy (SMA), although MN loss seems to be a late event. Conversely, disruption of afferent synapses on MNs has beenExpand
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