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GSK-3-selective inhibitors derived from Tyrian purple indirubins.
6-bromoindirubins provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3, and closely mimicked Wnt signaling in Xenopus embryos. Expand
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Using the cocrystal structures of various indirubins with GSK-3beta, CDK2 and CDK5/p25, this modeling approach provided some insight into the molecular basis of indirUBins' action and selectivity and allowed some improvements of this family of bis-indoles as kinase inhibitors to be forecast. Expand
The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits.
Oleuropein, for 3 or 6 wk, reduced the infarct size, conferred strong antioxidant protection and reduced the circulating lipids, and this is the first experimental study in vivo that suggests the possibility of using an olive constituent in the treatment of ischemia. Expand
Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
The content of polyphenols in table olives is highly influenced by the olive variety and the debittering process applied on the fruits, so an approximate quantity of 25 mg of oleuropein per day can be considered as safe for human use, since it can be found in the usual diet. Expand
In Vitro and In Vivo Activities of Chios Mastic Gum Extracts and Constituents against Helicobacter pylori
Results show that administration of TMEWP may be effective in reducing H. pylori colonization and that the major triterpenic acids in the acid extract may be responsible for such an activity. Expand
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
The new derivatives with an extended amino side chain attached at position 3' showed potent GSK-3 inhibitory activity, enhanced selectivity, and dramatically increased water solubility, suggesting that they might constitute tools to investigate circadian rhythm regulation. Expand
Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties
Abstract Grape stems constitute a scarcely investigated class of vinification byproducts with limited reports on their bioactive polyphenol content and/or industrial applications. Herein we presentExpand
Phenolic Constituents of Selaginella doederleinii.
Lignans are described here for the first time in the family Selaginellaceae for their cytotoxic activity against L 929 murine cells accounts for the use of the plant in traditional Chinese medicine as an anticancer agent. Expand
A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
A pilot scale system for the treatment of the olive oil mills wastewater was developed aiming at the recovery of high added value-contained polyphenols and the reduction of the environmental problems. Expand
Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts.
Abstract The comparative quantization of main non-coloured polyphenols, the assessment of total polyphenolic content (TPC) and the detailed evaluation of the antioxidant activities of variousExpand