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GSK-3-selective inhibitors derived from Tyrian purple indirubins.
Gastropod mollusks have been used for over 2500 years to produce the "Tyrian purple" dye made famous by the Phoenicians. This dye is constituted of mixed bromine-substituted indigo and indirubinExpand
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Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Pharmacological inhibitors of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinases have a promising potential for applications against several neurodegenerative diseases such asExpand
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Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties
Abstract Grape stems constitute a scarcely investigated class of vinification byproducts with limited reports on their bioactive polyphenol content and/or industrial applications. Herein we presentExpand
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Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
The content of polyphenols in table olives is highly influenced by the olive variety and the debittering process applied on the fruits. Nine commercial types of Greek table olives were examined forExpand
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Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Glycogen synthase kinase -3 (GSK-3) is a key enzyme involved in numerous physiological events and in major diseases, such as Alzheimer's disease, diabetes, and cardiac hypertrophy. Indirubins areExpand
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In Vitro and In Vivo Activities of Chios Mastic Gum Extracts and Constituents against Helicobacter pylori
ABSTRACT The extracts and pure major constituents of Chios mastic gum (resin of Pistacia lentiscus var. chia) were tested for their activities against Helicobacter pylori. A total mastic extractExpand
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Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts.
Abstract The comparative quantization of main non-coloured polyphenols, the assessment of total polyphenolic content (TPC) and the detailed evaluation of the antioxidant activities of variousExpand
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A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
The high polyphenol content of the wastewater is the major environmental problem caused by the olive mills. A pilot scale system for the treatment of the olive oil mills wastewater was developedExpand
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From olive drupes to olive oil. An HPLC-orbitrap-based qualitative and quantitative exploration of olive key metabolites.
The aim of the current study was the qualitative exploration and quantitative monitoring of key olive secondary metabolites in different production steps (drupes, paste, first and final oil)Expand
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Chemical Composition And In-Vitro Antimicrobial Activity Of The Essential Oils Of Three Greek Achillea Species
The chemical composition of the essential oils of Achillea holosericea, Achillea taygetea, Achillea fraasii was determined by GC/MS analysis. Among the ninety-five assayed constituents, camphor,Expand
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