GSK-3-selective inhibitors derived from Tyrian purple indirubins.
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
- P. Polychronopoulos, P. Magiatis, L. Meijer
- Biology, ChemistryJournal of Medicinal Chemistry
- 8 January 2004
Using the cocrystal structures of various indirubins with GSK-3beta, CDK2 and CDK5/p25, this modeling approach provided some insight into the molecular basis of indirUBins' action and selectivity and allowed some improvements of this family of bis-indoles as kinase inhibitors to be forecast.
The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits.
Oleuropein, for 3 or 6 wk, reduced the infarct size, conferred strong antioxidant protection and reduced the circulating lipids, and this is the first experimental study in vivo that suggests the possibility of using an olive constituent in the treatment of ischemia.
In Vitro and In Vivo Activities of Chios Mastic Gum Extracts and Constituents against Helicobacter pylori
- S. Paraschos, P. Magiatis, A. Skaltsounis
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 20 November 2006
Results show that administration of TMEWP may be effective in reducing H. pylori colonization and that the major triterpenic acids in the acid extract may be responsible for such an activity.
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
The new derivatives with an extended amino side chain attached at position 3' showed potent GSK-3 inhibitory activity, enhanced selectivity, and dramatically increased water solubility, suggesting that they might constitute tools to investigate circadian rhythm regulation.
Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties
Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
- E. Zoidou, E. Melliou, E. Gikas, A. Tsarbopoulos, P. Magiatis, A. Skaltsounis
- Chemistry, MedicineJournal of agricultural and food chemistry
- 13 January 2010
The content of polyphenols in table olives is highly influenced by the olive variety and the debittering process applied on the fruits, so an approximate quantity of 25 mg of oleuropein per day can be considered as safe for human use, since it can be found in the usual diet.
Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts.
1H NMR-based metabonomics for the classification of Greek wines according to variety, region, and vintage. Comparison with HPLC data.
- Maria Anastasiadi, Athina Zira, P. Magiatis, S. Haroutounian, A. Skaltsounis, E. Mikros
- Mathematics, MedicineJournal of Agricultural and Food Chemistry
- 9 December 2009
A sensitive and simple method was developed for the classification of wines according to variety, geographical origin, and vintage using NMR-based metabonomics. Polyphenol-rich extracts were prepared…
A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
- A. Agalias, P. Magiatis, Thrasyvoulos Manios
- EngineeringJournal of agricultural and food chemistry
- 10 March 2007
A pilot scale system for the treatment of the olive oil mills wastewater was developed aiming at the recovery of high added value-contained polyphenols and the reduction of the environmental problems.