Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.

@article{Kritsanida2009SynthesisAA,
  title={Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.},
  author={M. Kritsanida and P. Magiatis and A. Skaltsounis and Youyi Peng and P. Li and L. Wennogle},
  journal={Journal of natural products},
  year={2009},
  volume={72 12},
  pages={
          2199-202
        }
}
  • M. Kritsanida, P. Magiatis, +3 authors L. Wennogle
  • Published 2009
  • Chemistry, Medicine
  • Journal of natural products
  • The bis-indole alkaloid indirubin and its analogues bear a very interesting natural pharmacophore. They are recognized mainly as kinase inhibitors, but several other activities make them possible candidates for preclinical studies. Based on the previously reported activity of 7-bromoindirubin-3'-oxime and its derivatives, the synthesis of indirubins bearing a heterocyclic nitrogen atom at position 7 was carried out. Herein, we report the first synthesis of 7-azaindirubin-3'-oxime (12) as well… CONTINUE READING
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