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Angiotensin II (AngII)-induced superoxide (O2(•-)) production by the NADPH oxidases and mitochondria has been implicated in… Expand Background:Preexposure of brain to isoflurane, a commonly used anesthetic, induces ischemic tolerance. This phenomenon is called… Expand Endogenous H2S is synthesized mainly by cystathionine γ-lyase in the heart. The present study investigated the role of H2S in… Expand &NA; Carbon monoxide, which is generated in mammals during the degradation of heme by the enzyme heme oxygenase, is an important… Expand Cardiac ischemia/reperfusion (IR) injury is associated with mitochondrial (m)Ca2+ overload. Anesthetic preconditioning (APC… Expand K(+) channel openers have been recently recognized for their ability to protect mitochondria from anoxic injury. Yet the… Expand The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) stimulate cellular proliferation and affect… Expand Prolonged myocardial ischemia results in an increase in intracellular calcium concentration ([Ca(2+)]i), which is thought to play… Expand 1 Mitochondrial dysfunction, secondary to excessive accumulation of Ca2+, has been implicated in cardiac injury. We here examined… Expand BACKGROUND
Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The… Expand