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Heat‐Shock Response Is Associated With Enhanced Postischemic Ventricular Recovery
In cells, hyperthermia induces synthesis of heat-shock proteins and the acquisition of thermotolerance. Thermotolerant cells are resistant to subsequent oxidative stress. In this study, heat-shockedExpand
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The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease.
The Na(+)-H(+) exchange (NHE) is a major mechanism by which the heart adapts to intracellular acidosis during ischemia and recovers from the acidosis after reperfusion. There are at least 6 NHEExpand
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Exercise Improves Postischemic Cardiac Function in Males but Not Females: Consequences of a Novel Sex-Specific Heat Shock Protein 70 Response
Exercise is a physiological inducer of the cardioprotective heat shock protein, Hsp70. The putative biological events involved in signaling this response exhibit sexual dimorphism. Thus, it wasExpand
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Role of Na+/H+ exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox.
Na+/H+ exchange, an electroneutral cotransport system, is activated by reperfusion of the ischaemic heart. While activation can restore intracellular pH following an acid load, the concomitantExpand
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Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases
In addition to their central role in ATP synthesis, mitochondria play a critical role in cell death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated phosphate levelsExpand
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Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.
Adipokines represent a family of proteins released by adipocytes that affect various biological processes including metabolism, satiety, inflammation, and cardiovascular function. The first adipokineExpand
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Amiloride enhances postischemic ventricular recovery: possible role of Na+-H+ exchange.
  • M. Karmazyn
  • Medicine
  • The American journal of physiology
  • 1 September 1988
Amiloride (40 micrograms/ml) was studied in the isolated rat heart subjected to low-flow ischemia followed by reperfusion. Reperfusion after 30 min of ischemia produced recoveries of force, rate ofExpand
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The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes
One of the major manifestations of obesity is increased production of the adipocyte-derived 16-kDa peptide leptin, which is also elevated in heart disease, including congestive heart failure.Expand
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Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats.
We investigated the effect of sodium/hydrogen exchange inhibition (NHE-1) on hypertrophy and heart failure after coronary artery ligation (CAL) in the rat. Animals were subjected to occlusion (orExpand
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Diabetes-induced myocardial structural changes: role of endothelin-1 and its receptors.
Several metabolic abnormalities may be triggered secondary to hyperglycemia in diabetes. Some of these abnormalities may alter expression of vasoactive factors in the target organs of diabeticExpand
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