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Heat‐Shock Response Is Associated With Enhanced Postischemic Ventricular Recovery
In cells, hyperthermia induces synthesis of heat-shock proteins and the acquisition of thermotolerance. Thermotolerant cells are resistant to subsequent oxidative stress. In this study, heat-shocked… Expand
The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease.
- M. Karmazyn, X. T. Gan, R. A. Humphreys, H. Yoshida, K. Kusumoto
- Circulation research
- 29 October 1999
The Na(+)-H(+) exchange (NHE) is a major mechanism by which the heart adapts to intracellular acidosis during ischemia and recovers from the acidosis after reperfusion. There are at least 6 NHE… Expand
Exercise Improves Postischemic Cardiac Function in Males but Not Females: Consequences of a Novel Sex-Specific Heat Shock Protein 70 Response
Exercise is a physiological inducer of the cardioprotective heat shock protein, Hsp70. The putative biological events involved in signaling this response exhibit sexual dimorphism. Thus, it was… Expand
Role of Na+/H+ exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox.
Na+/H+ exchange, an electroneutral cotransport system, is activated by reperfusion of the ischaemic heart. While activation can restore intracellular pH following an acid load, the concomitant… Expand
Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases
- S. Javadov, M. Karmazyn, Nelson Escobales
- Medicine, Chemistry
- Journal of Pharmacology and Experimental…
- 1 September 2009
In addition to their central role in ATP synthesis, mitochondria play a critical role in cell death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated phosphate levels… Expand
Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.
Adipokines represent a family of proteins released by adipocytes that affect various biological processes including metabolism, satiety, inflammation, and cardiovascular function. The first adipokine… Expand
Amiloride enhances postischemic ventricular recovery: possible role of Na+-H+ exchange.
- M. Karmazyn
- The American journal of physiology
- 1 September 1988
Amiloride (40 micrograms/ml) was studied in the isolated rat heart subjected to low-flow ischemia followed by reperfusion. Reperfusion after 30 min of ischemia produced recoveries of force, rate of… Expand
The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes
- V. Rajapurohitam, X. T. Gan, L. Kirshenbaum, M. Karmazyn
- Biology, Medicine
- Circulation research
- 22 August 2003
One of the major manifestations of obesity is increased production of the adipocyte-derived 16-kDa peptide leptin, which is also elevated in heart disease, including congestive heart failure.… Expand
Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats.
We investigated the effect of sodium/hydrogen exchange inhibition (NHE-1) on hypertrophy and heart failure after coronary artery ligation (CAL) in the rat. Animals were subjected to occlusion (or… Expand
Diabetes-induced myocardial structural changes: role of endothelin-1 and its receptors.
- S. Chen, T. Evans, K. Mukherjee, M. Karmazyn, S. Chakrabarti
- Journal of molecular and cellular cardiology
- 1 September 2000
Several metabolic abnormalities may be triggered secondary to hyperglycemia in diabetes. Some of these abnormalities may alter expression of vasoactive factors in the target organs of diabetic… Expand