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5-hydroxydecanoate

National Institutes of Health

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5-hydroxydecanoic acid

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Highly Cited
2007
Highly Cited
2007
Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling.
Highly Cited
2005
Highly Cited
2005
Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity
Background—Sildenafil, a phosphodiesterase-5 inhibitor, induces cardioprotection against ischemia/reperfusion injury via opening… 
Highly Cited
2002
Highly Cited
2002
KATP channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart
Diazoxide and 5‐hydroxydecanoate (5‐HD; C10:0) are reputed to target specifically mitochondrial ATP‐sensitive K+ (KATP) channels… 
Highly Cited
2002
Highly Cited
2002
Volatile Anesthetics Mimic Cardiac Preconditioning by Priming the Activation of Mitochondrial KATP Channels via Multiple Signaling Pathways
Background Volatile anesthetics induce pharmacological preconditioning in cardiac tissue. The purpose of this study was to test… 
Highly Cited
2001
Highly Cited
2001
Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection.
Highly Cited
2000
Highly Cited
2000
Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle.
Highly Cited
2000
Highly Cited
2000
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Cardiomyocyte death after ischemia/reperfusion correlates with oxidant stress, and antioxidants confer protection in that model… 
Highly Cited
1998
Highly Cited
1998
State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate.
The mitochondrial KATP channel (mitoKATP) is hypothesized to be the receptor for the cardioprotective effects of K+ channel… 
Highly Cited
1998
Highly Cited
1998
Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.
Pharmacological openers of mitochondrial ATP-dependent K+ (mitoKATP) channels mimic ischemic preconditioning, and such… 
Highly Cited
1992
Highly Cited
1992
Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.
OBJECTIVE The aims were: (1) to determine if a new ischaemia selective ATP dependent potassium (KATP) channel antagonist, sodium… 
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