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Management of bleeding and coagulopathy following major trauma: an updated European guideline
Key changes encompassed in this version of the guideline include new recommendations on the appropriate use of vasopressors and inotropic agents, and reflect an awareness of the growing number of patients in the population at large treated with antiplatelet agents and/or oral anticoagulants. Expand
The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition
The guideline now recommends that patients be transferred directly to an appropriate trauma treatment centre and encourages use of a restricted volume replacement strategy during initial resuscitation, and may also serve as a basis for local implementation. Expand
Management of bleeding following major trauma: an updated European guideline
This document presents an updated version of the guideline for the management of bleeding following severe injury, which provides an evidence-based multidisciplinary approach to themanagement of critically injured bleeding trauma patients. Expand
Activity‐based costs of blood transfusions in surgical patients at four hospitals
Determining the cost of supplying patients with blood transfusions requires an in‐depth examination of the complex array of activities surrounding the decision to transfuse. Expand
Anemia and Patient Blood Management in Hip and Knee Surgery: A Systematic Review of the Literature
  • D. Spahn
  • Medicine
  • Anesthesiology
  • 1 August 2010
Treatment of preoperative anemia with iron, with or without erythropoietin, and perioperative cell salvage decreased the need for blood transfusion and may contribute to improved patient outcomes. Expand
Prevention of Atelectasis Formation During the Induction of General Anesthesia in Morbidly Obese Patients
In morbidly obese patients, atelectasis formation is largely prevented by PEEP applied during the anesthetic induction and is associated with a better oxygenation. Expand
The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition
Advances in the understanding of the pathophysiology of post-traumatic coagulopathy have supported improved management strategies, including evidence that early, individualised goal-directed treatment improves the outcome of severely injured patients. Expand
Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse
Two variants of the SNI model are tested and it is found that injuring the tibial nerve alone induces mechanical hypersensitivity, while injuring the common peroneal and sural nerves together does not induce any significant increase in mechanical sensitivity in the territory of the spared tibIAL nerve. Expand
Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction.
It is proposed that, apart from low coronary risk situations, patients on antiplatelet drugs should continue their treatment throughout surgery, except when bleeding might occur in a closed space, and a therapeutic bridge with shorter-acting anti platelet drugs may be considered. Expand
International consensus statement on the peri‐operative management of anaemia and iron deficiency
A diagnostic approach for anaemia and iron deficiency in surgical patients; identification of patients appropriate for treatment; and advice on practical management and follow‐up are developed. Expand