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5-deazamethotrexate

National Institutes of Health

Related topics

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3 relations

Broader (2)

Folic Acid AntagonistsMethotrexate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1988
1988
Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor…
Studies are described examining a new class of 4-aminofolate analogues modified by an N to C conversion and alkyl substitution at… 
Highly Cited
1986
Highly Cited
1986
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with… 
1984
1984
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
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