Skip to search formSkip to main contentSkip to account menu
You are currently offline. Some features of the site may not work correctly.

5-deazamethotrexate

National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Folic Acid AntagonistsMethotrexate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1988
1988
Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor…
Studies are described examining a new class of 4-aminofolate analogues modified by an N to C conversion and alkyl substitution at… 
  • figure 1
  • table 1
  • figure 2
  • table 2
  • table 3
Highly Cited
1986
Highly Cited
1986
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with… 
1984
1984
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
The inhibition of dihydrofolate reductases from Escherichia coli and chicken liver by folate, methotrexate, aminopterin and their… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE