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Methotrexate

Known as: Méthotrexate, 4-Amino-10-methylfolic Acid, 4-amino-N(10)-Methylpteroylglutamic acid 
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
OBJECTIVE To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab… Expand
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Review
2005
Review
2005
BACKGROUND Quinquennial overviews (1985-2000) of the randomised trials in early breast cancer have assessed the 5 year and 10… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To compare the benefits of initiating treatment with methotrexate (MTX) and infliximab (anti-tumor necrosis factor… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Methotrexate is the most frequent choice of disease-modifying antirheumatic therapy for rheumatoid arthritis. Although… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Etanercept, which blocks the action of tumor necrosis factor, reduces disease activity in patients with long-standing… Expand
Highly Cited
2000
Highly Cited
2000
BACKGROUND Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Patients treated with methotrexate for rheumatoid arthritis often improve but continue to have active disease. This… Expand
Review
1988
Review
1988
Methotrexate (MTX) has become an important drug in the treatment of rheumatoid arthritis (RA). The American College of… Expand
Highly Cited
1985
Highly Cited
1985
Twenty-eight patients with refractory rheumatoid arthritis completed a randomized 24-week double-blind crossover trial comparing… Expand
Review
1983
Review
1983
METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse… Expand