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Methotrexate

Known as: Méthotrexate, 4-Amino-10-methylfolic Acid, 4-amino-N(10)-Methylpteroylglutamic acid 
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (16)

AWO54COMPE protocolDD1 protocolEmthexat
Alcoholic Liver DiseasesCMF-B protocolCMFVP protocolCOPAD protocol

Broader (1)

Dermatologic Agents

Papers overview

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Highly Cited
2010
Highly Cited
2010
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a…
Review
2005
Review
2005
Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis
Methotrexate administered weekly in low doses is a mainstay in the therapy of rheumatoid arthritis. Although originally developed… 
Review
2002
Review
2002
Molecular action of methotrexate in inflammatory diseases
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy… 
Highly Cited
1998
Highly Cited
1998
Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow…
We report the results of a phase III open-label, randomized, multicenter trial comparing tacrolimus/methotrexate to cyclosporine… 
Highly Cited
1994
Highly Cited
1994
Methotrexate for Rheumatoid Arthritis
Methotrexate (MTX) has become an important drug in the treatment of rheumatoid arthritis (RA). The American College of… 
Highly Cited
1986
Highly Cited
1986
Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia.
We treated 93 patients who had acute nonlymphoblastic leukemia in the first remission or chronic myelocytic leukemia in the… 
Review
1985
Review
1985
Polyglutamation of methotrexate. Is methotrexate a prodrug?
La polyglutamation est assuree par la folyl polyglutamyl synthetase. Leur etude decrit l'importance pharmacologique de la… 
Review
1983
Review
1983
The pharmacology and clinical use of methotrexate.
METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse… 
Highly Cited
1975
Highly Cited
1975
Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections.
The kinetics and distribution of methotrexate in intraventricular and intrathecal cerebrospinal-fluid spaces were studied in… 
Highly Cited
1956
Highly Cited
1956
Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma
Summary 1) Two patients with choriocarcinoma and one with chorioadenoma destruens with proven progressive metastases were treated… 
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