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Methotrexate

Known as: Méthotrexate, 4-Amino-10-methylfolic Acid, 4-amino-N(10)-Methylpteroylglutamic acid 
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (16)

AWO54COMPE protocolDD1 protocolEmthexat
Alcoholic Liver DiseasesCMF-B protocolCMFVP protocolCOPAD protocol

Broader (1)

Dermatologic Agents

Papers overview

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Highly Cited
1980
Highly Cited
1980
Methotrexate polyglutamate synthesis by cultured human breast cancer cells.
We studied the conversion of methotrexate to poly-gamma-glutamyl derivatives by cultured human breast cancer cells. After… 
Highly Cited
1979
Highly Cited
1979
Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.
Abstract The transport and metabolism of methotrexate (MTX) have been examined in monolayer cultures of a cell line derived from… 
Highly Cited
1977
Highly Cited
1977
Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection.
: Cerebrospinal fluid (CSF) and plasma methotrexate (MTX) concentrations were measured in 76 children and adults who received… 
1972
1972
Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro.
A graded series of amethopterin-resistant sublines maintained at concentrations varying from 0.1 to 50.0 μg/ml were selected in… 
Highly Cited
1970
Highly Cited
1970
Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate.
Summary A brain tumor model has been utilized to test 4 chemotherapeutic agents. The model consists of C57BL male mice implanted… 
Highly Cited
1969
Highly Cited
1969
The effect of methotrexate on enzymes induced following partial hepatectomy.
The synthesis of thymidine kinase, thymidylate kinase, thymidylate synthetase, DNA polymerase, and deoxycytidylate deaminase was… 
1968
1968
Dihydrofolate reductase of Streptococcus faicium. II. Purification and some properties of two dihydrofolate reductases from the amethopterin-resistant mutant Streptococcus faecium var. Durans strain…
Abstract From a single amethopterin-resistant organism, Streptococcus faecium var. durans strain A, two different dihydrofolate… 
1967
1967
Amethopterin transport in Ehrlich ascites carcinoma and L1210 cells.
SUMMARY Accumulation of amethopterin by L1210 and Ehrlich ascites cells in miro was mediated by a slow, temperature-sensitive… 
1960
1960
The antileukemic action of two thiadiazole derivatives.
Summary The thiadiazole derivatives 2-amino-1,3-4-thiadiazole and 2-ethylamino-1,3,4-thiadiazole retarded the growth of leukemia… 
1959
1959
Nutritional and amethopterin-resistant characteristics of leukemic clones.
Development of media which support the cont inuous reproduction in culture of two pure cell lines of mouse leukemic cells (L5178…