Methotrexate

Known as: Méthotrexate, 4-Amino-10-methylfolic Acid, 4-amino-N(10)-Methylpteroylglutamic acid 
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management… (More)
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Review
2017
Review
2017
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the… (More)
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Review
2016
Review
2016
Anthracyclines, e.g., doxorubicin (DOX), and anthracenediones, e.g., mitoxantrone (MTX), are drugs used in the chemotherapy of… (More)
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Review
2016
Review
2016
The treatment and outcomes of patients with rheumatoid arthritis (RA) have been transformed over the past two decades. Low… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To compare the benefits of initiating treatment with methotrexate (MTX) and infliximab (anti-tumor necrosis factor… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Methotrexate is the most frequent choice of disease-modifying antirheumatic therapy for rheumatoid arthritis. Although… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Etanercept, which blocks the action of tumor necrosis factor, reduces disease activity in patients with long-standing… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Patients treated with methotrexate for rheumatoid arthritis often improve but continue to have active disease. This… (More)
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