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Methotrexate

Known as: Méthotrexate, 4-Amino-10-methylfolic Acid, 4-amino-N(10)-Methylpteroylglutamic acid 
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (16)

AWO54COMPE protocolDD1 protocolEmthexat
Alcoholic Liver DiseasesCMF-B protocolCMFVP protocolCOPAD protocol

Broader (1)

Dermatologic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy.
Thymidine phosphorylase (TP), an enzyme involved in the thymidine synthesis and degradation, has been shown to promote tumor… 
Highly Cited
1979
Highly Cited
1979
Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.
Abstract The transport and metabolism of methotrexate (MTX) have been examined in monolayer cultures of a cell line derived from… 
Highly Cited
1977
Highly Cited
1977
Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection.
: Cerebrospinal fluid (CSF) and plasma methotrexate (MTX) concentrations were measured in 76 children and adults who received… 
Highly Cited
1969
Highly Cited
1969
The effect of methotrexate on enzymes induced following partial hepatectomy.
The synthesis of thymidine kinase, thymidylate kinase, thymidylate synthetase, DNA polymerase, and deoxycytidylate deaminase was… 
Highly Cited
1969
Highly Cited
1969
Response of a “Resistant” Plasmacytoma to Alkylating Agents and X-Ray in Combination with the “Excision Repair Inhibitors Caffeine and Chloroquine∗
One of the frustrating aspects of tumor therapy has been the resistance developed by tumors to the agents used therapeutically… 
Highly Cited
1969
Highly Cited
1969
Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors.
Abstract Energy-dependent transport of the folic acid analogue, methotrexate, was studied in L1210 murine leukemia cells. A… 
1968
1968
Dihydrofolate reductase of Streptococcus faicium. II. Purification and some properties of two dihydrofolate reductases from the amethopterin-resistant mutant Streptococcus faecium var. Durans strain…
Abstract From a single amethopterin-resistant organism, Streptococcus faecium var. durans strain A, two different dihydrofolate… 
1967
1967
Amethopterin transport in Ehrlich ascites carcinoma and L1210 cells.
SUMMARY Accumulation of amethopterin by L1210 and Ehrlich ascites cells in miro was mediated by a slow, temperature-sensitive… 
Highly Cited
1962
Highly Cited
1962
The association of increased dihydrofolate reductase with amethopterin resistance in mouse leukemia.
New antifolate-resistant sublines of mouse leukemia L1210 have been developed. Dihydrofolate reductase activities were determined… 
1959
1959
Nutritional and amethopterin-resistant characteristics of leukemic clones.
Development of media which support the cont inuous reproduction in culture of two pure cell lines of mouse leukemic cells (L5178… 
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