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Methotrexate

Known as: Méthotrexate, 4-Amino-10-methylfolic Acid, 4-amino-N(10)-Methylpteroylglutamic acid 
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (16)

AWO54COMPE protocolDD1 protocolEmthexat
Alcoholic Liver DiseasesCMF-B protocolCMFVP protocolCOPAD protocol

Broader (1)

Dermatologic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Acute promyelocytic leukemia with, t( 15; 17) abnormality after, chemotherapy containing etoposide for, Langerhans cell histiocytosis
of their disease. Obviously, a randomized double-blind study is a much better design to assess drug efficacy. However, we… 
Highly Cited
1984
Highly Cited
1984
Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma.
Highly Cited
1984
Highly Cited
1984
Recurrent chromosomal defects are found in most patients with acute nonlymphocytic leukemia.
Highly Cited
1981
Highly Cited
1981
Mid-prophase human chromosomes. The attainment of 2000 bands
SummaryHuman mid-prophase chromosomes exposed to amethopterin, actinomycin D, and bromodeoxyuridine display more than 2000 bands… 
Highly Cited
1981
Highly Cited
1981
PRESYMPTOMATIC CENTRAL NERVOUS SYSTEM THERAPY IN PREVIOUSLY UNTREATED CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA: COMPARISON OF 1800 RAD AND 2400 RAD A Report for Children's Cancer Study Group
Highly Cited
1980
Highly Cited
1980
Size heterogeneity in the 3′ end of dihydrofolate reductase messenger RNAs in mouse cells
Highly Cited
1976
Highly Cited
1976
Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
Three mechanisms for resistance to methotrexate (Mtx) have been identified in Chinese hamster ovary (CHO) cells selected for… 
Highly Cited
1971
Highly Cited
1971
Thymidylate synthetase from amethopterin-resistant Lactobacillus casei.
Highly Cited
1961
Highly Cited
1961
Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.
Highly Cited
1958
Highly Cited
1958
Intrathecal amethopterin in neurological manifestations of leukemia.
The difficulty in managing acute leukemia in children is enhanced by the occurrence of neurological manifestations. It is… 
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