Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.
- F. Schabel, T. Johnston, G. Mccaleb, J. Montgomery, W. R. Laster, H. Skipper
- BiologyCancer Research
- 1 June 1963
Evidence has been obtained which suggests that the mechanism of action of 1-methyl-1-nitrosourea and 1,3-bis(2-chloroethyl)-1- nitrogenous may be similar to that of certain well known alkylating agent-sensitive and -resistant plasmacytoma in hamsters.
The modes of decomposition of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.
- J. Montgomery, R. James, G. Mccaleb, T. Johnston
- ChemistryJournal of Medicinal Chemistry
- 1 July 1967
Comparison of the properties of metabolites of CCNU.
- G. P. Wheeler, T. Johnston, B. Bowdon, G. Mccaleb, D. L. Hill, J. Montgomery
- ChemistryBiochemical Pharmacology
- 15 December 1977
Synthesis of chlorozotocin, the 2-chloroethyl analog of the anticancer antibiotic streptozotocin.
- T. Johnston, G. Mccaleb, J. Montgomery
- ChemistryJournal of Medicinal Chemistry
- 1975
The synthesis of potential anticancer agents. XXXVI. N-nitrosoureas. II. Haloalkyl derivatives.
- T. Johnston, G. Mccaleb, P. Opliger, J. Montgomery
- ChemistryJournal of Medicinal Chemistry
- 1 November 1966
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
- J. R. Piper, G. Mccaleb, J. Montgomery, R. Kisliuk, Y. Gaumont, F. Sirotnak
- ChemistryJournal of Medicinal Chemistry
- 1 June 1986
Investigation of 5-methyl-5-deaza analogues for their effect on cell growth inhibition, transport characteristics, and net accumulation of polyglutamate forms revealed the analogues to have essentially the same properties as the appropriate parent compound, aminopterin or methotrexate (MTX), except that 20 and 21 were approximately 10 times more growth inhibitory than MTX.
Decomposition of N-(2-chloroethyl)-N-nitrosoureas in aqueous media.
- J. Montgomery, R. James, G. Mccaleb, M. Kirk, T. Johnston
- ChemistryJournal of Medicinal Chemistry
- 1 June 1975
A reinvestigation of the aqueous decomposition of N-(2-chloroethyl)-N-nitrosoureas has shown that their mode of decomposition is dependent upon whether or not the solution is buffered at or near…
THE SYNTHESIS OF ANTINEOPLASTIC AGENTS. XXXII. N-NITROSOUREAS. I.
- T. Johnston, G. Mccaleb, J. Montgomery
- ChemistryJournal of Medicinal Chemistry
- 1 November 1963
Synthesis of potential anticancer agents. 38. N-Nitrosoureas. 4. Further synthesis and evaluation of haloethyl derivatives.
- T. Johnston, G. Mccaleb, P. Opliger, W. Laster, J. Montgomery
- ChemistryJournal of Medicinal Chemistry
- 1 July 1971
Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents.
- T. Johnston, G. Mccaleb, S. D. Clayton, J. Frye, C. A. Krauth, J. Montgomery
- ChemistryJournal of Medicinal Chemistry
- 1 February 1977
The superior activity of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas…
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