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5-deazaaminopterin

Known as: L-Glutamic acid, N-(4-(((2,4-diaminopyrido(2,3-d)pyrimidin-6-yl)methyl)amino)benzoyl)- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AminopterinFolic Acid Antagonists
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1992
1992
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
5-Deaza-10-propargylfolic acid (4), an analogue of the thymidylate synthase (TS) inhibitor 10-propargyl-5,8-dideazafolic acid… 
1988
1988
Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor…
Studies are described examining a new class of 4-aminofolate analogues modified by an N to C conversion and alkyl substitution at… 
1986
1986
Synthesis and biological activities of 5-deaza analogues of aminopterin and folic acid.
N-[p-[[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl] amino]benzoyl]-L-glutamic acid (1a, 5-deazaaminopterin) and the 5-methyl… 
1984
1984
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
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