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Synthesis and Antifolate Evaluation of the Aminopterin Analogue with a Bicyclo[2.2.2]octane Ring in Place of the Benzene Ring.
Synthesis and Antifolate Evaluation of 10‐Ethyl‐5‐methyl‐5,10‐ dideazaaminopterin and an Alternative Synthesis of 10‐Ethyl‐10‐ deazaaminopterin (Edatrexate).
Analogues of 10‐Deazaaminopterin and 5‐Alkyl‐5,10‐dideazaaminopterin with the 4‐Substituted 1‐Naphthoyl Group in the Place of 4‐Substituted Benzoyl.
FURTHER EVALUATION OF 5-ALKYL-5-DEAZA ANTIFOLATES. 5-PROPYL- AND 5-BUTYL-5-DEAZA ANALOGUES OF AMINOPTERIN AND METHOTREXATE
5-Propyl-5-deaza and 5-butyl-5-deaza analogues of classical antifolates were synthesized by extensions of a previously reported general route which proceeds through… Expand
Further Evaluation of 5‐Alkyl‐5‐deaza Antifolates. 5‐Propyl‐ and 5‐ Butyl‐5‐deaza Analogues of Aminopterin and Methotrexate.