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5-aminolevulinate synthase activity

Known as: aminolevulinic acid synthase activity, 5-aminolevulinate synthetase activity, 5-aminolevulinic acid synthase activity 
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA. [EC:2.3.1.37, RHEA:12924]
National Institutes of Health

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5-Aminolevulinate synthase

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Highly Cited
1990
Highly Cited
1990
Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.
Cytochromes P-450IIB1 and P-450IIB2 were recently shown to be inducible in rat hepatocyte cultures maintained on a reconstituted… 
1987
1987
Effects of phorone (diisopropylidene acetone), a glutathione (GSH) depletor, on hepatic enzymes involved in drug and heme metabolism in rats: evidence that phorone is a potent inducer of heme…
Highly Cited
1986
Highly Cited
1986
Bacterial delta-aminolevulinic acid synthase activity is not essential for leghemoglobin formation in the soybean/Bradyrhizobium japonicum symbiosis.
Previous studies of legume nodules have indicated that formation of the heme moiety of leghemoglobin is a function of the… 
Highly Cited
1977
Highly Cited
1977
Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.
Highly Cited
1976
Highly Cited
1976
Erythroid differentiation in cultured Friend leukemia cells treated with metabolic inhibitors.
The induction of erythroid differentiation in the T3-C12 clone of Friend leukemia cells by dimethyl sulfoxide is accompanied by… 
Highly Cited
1974
Highly Cited
1974
A microassay for uroporphyrinogen I synthase, one of three abnormal enzyme activities in acute intermittent porphyria, and its application to the study of the genetics of this disease.
A new spectrofluorometric assay is described for quantitating uroporphyrinogen I synthase (EC 4.3.1.8) activity in volumes of… 
Highly Cited
1972
Highly Cited
1972
Decreased red cell uroporphyrinogen I synthetase activity in intermittent acute porphyria.
Intermittent acute porphyria has recently been distinguished biochemically from other genetic hepatic porphyrias by the… 
Highly Cited
1970
Highly Cited
1970
Heme biosynthesis in intermittent acute prophyria: decreased hepatic conversion of porphobilinogen to porphyrins and increased delta aminolevulinic acid synthetase activity.
Hepatic conversion of porphobilinogen to porphyrins was less than 50% of control levels in human subjects with the genetic… 
1970
1970
Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations.
Highly Cited
1969
Highly Cited
1969
Mutant Strains of Rhodopseudomonas spheroides Lacking δ-Aminolevulinate Synthase: Growth, Heme, and Bacteriochlorophyll Synthesis
Two mutant strains of Rhodopseudomonas spheroides were described which lacked δ-aminolevulinate synthase activity. They required… 
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