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A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol.
  • S. Ulick, L. Levine, +6 authors M. New
  • Chemistry, Medicine
  • The Journal of clinical endocrinology and…
  • 1 November 1979
A syndrome is described whose features, suggestive of primary mineralcorticoid excess, included hypertension, hypokalemia, low PRA, and responsiveness to spironolactone. Aldosterone levels wereExpand
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Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood.
Whether environmental contaminants increase breast cancer risk among women on Long Island, NY, is unknown. The study objective is to determine whether breast cancer risk is increased in relation toExpand
  • 220
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Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice.
Indole-3-carbinol (I3C) is a potent inducer of cytochrome P450 enzymes in many species, including humans. We therefore studied alterations in the cytochrome P450-dependent metabolism of estradiol inExpand
  • 322
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Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.
OBJECTIVE Most precancerous lesions of the cervix are treated with surgery or ablative therapy. Chemoprevention, using natural and synthetic compounds, may intervene in the early precancerous stagesExpand
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2-hydroxyestrone: the 'good' estrogen.
The issue of the role of 2-hydroxyestrone (2-OHE1) in breast cancer has been the subject of considerable controversy as to whether it is carcinogenic or anticarcinogenic. The expanding data baseExpand
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Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.
The endogenous metabolism of estrogens is primarily oxidative and involves hydroxylation of the steroid at either C2 (2-OHE1) or C16 (16-OHE1). While the 2-OHE1 metabolites are essentially devoid ofExpand
  • 112
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Alterations of estrogen metabolism in systemic lupus erythematosus.
Estradiol metabolism in 10 patients with systemic lupus erythematosus (SLE) and 29 normal controls was studied by measurement of urinary metabolites after injection of labeled 3H-estradiol. PatientsExpand
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Low plasma androgens in women with systemic lupus erythematosus.
The high ratio of women with systemic lupus erythematosus (SLE) has remained unexplained, despite the recent description of metabolic abnormalities of estrogen and androgen metabolism. Alterations ofExpand
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Estrogen Metabolism and Risk of Breast Cancer: A Prospective Study of the 2:16&agr;-Hydroxyestrone Ratio in Premenopausal and Postmenopausal Women
Experimental and clinical evidence suggests that 16&agr;-hydroxylated estrogen metabolites, biologically strong estrogens, are associated with breast cancer risk, while 2-hydroxylated metabolites,Expand
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Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
The effect of route of administration on the ability of indole-3-carbinol (13C), an anticarcinogen present in cruciferous vegetables, to induce estradiol 2-hydroxylase (EH) in female rat liverExpand
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