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5-Aminolevulinate synthase

Known as: Aminolevulinic Acid Synthetase, Synthetase, 5-Aminolevulinate, delta Aminolevulinate Synthase 
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta… 
National Institutes of Health

Related topics

Related topics

12 relations
5-aminolevulinate synthase activityALAS1 geneIn BloodProcess of secretion

Narrower (2)

ALAS2 protein, humanProtoporphyria, Erythropoietic, X-Linked Dominant

Broader (1)

Acyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
Role of arginine 439 in substrate binding of 5-aminolevulinate synthase.
5-Aminolevulinate synthase (EC 2.3.1.37) catalyzes the first reaction in the heme biosynthetic pathway in nonplant eukaryotes and… 
Highly Cited
1992
Highly Cited
1992
In vivo and in vitro modulation of the mRNA-binding activity of iron-regulatory factor. Tissue distribution and effects of cell proliferation, iron levels and redox state.
The mRNA-binding protein, iron-regulatory factor (IRF) has a central role in iron metabolism. It coordinately increases… 
Highly Cited
1990
Highly Cited
1990
Transcriptional regulation of hydrogenase synthesis by nickel in Bradyrhizobium japonicum.
Nickel is a component of the H2-oxidizing hydrogenase of many bacteria. We report that nickel is required not only for the… 
1986
1986
Nucleotide sequence of the chicken 5-aminolevulinate synthase gene.
5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end… 
Highly Cited
1978
Highly Cited
1978
Heme is necessary for the accumulation and assembly of cytochrome c oxidase subunits in Saccharomyces cerevisiae.
1978
1978
Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Highly Cited
1973
Highly Cited
1973
STUDIES IN PORPHYRIA
Patients with the genetic liver disease, acute intermittent porphyria (AIP), have a defect in the reductive transformation of… 
Highly Cited
1970
Highly Cited
1970
Controls on chlorophyll synthesis in barley.
In 7- to 10-day-old leaves of etiolated barley (Hordeum vulgare), all of the enzymes that convert delta-aminolevulinic acid to… 
Highly Cited
1969
Highly Cited
1969
Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. IV. Accumulation of the enzyme in the soluble fraction of rat liver.
1965
1965
A model for calculating messenger RNA half-life: short lived messenger RNA in the induction of mammalian delta-aminolevulinic acid synthetase.
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