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5-Aminolevulinate synthase

Known as: Aminolevulinic Acid Synthetase, Synthetase, 5-Aminolevulinate, delta Aminolevulinate Synthase 
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta… 
National Institutes of Health

Related topics

Related topics

12 relations
5-aminolevulinate synthase activityALAS1 geneIn BloodProcess of secretion

Narrower (2)

ALAS2 protein, humanProtoporphyria, Erythropoietic, X-Linked Dominant

Broader (1)

Acyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1982
Highly Cited
1982
Heme biosynthesis in Rhizobium. Identification of a cloned gene coding for delta-aminolevulinic acid synthetase from Rhizobium meliloti.
Highly Cited
1975
Highly Cited
1975
Heme synthetase deficiency in human protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts.
The final step in heme biosynthesis is chelation of porphyrin with Fe++ catalyzed by the mitochondrial enzyme heme synthetase. We… 
Highly Cited
1975
Highly Cited
1975
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450.
Highly Cited
1975
Highly Cited
1975
Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin…
Review
1975
Review
1975
Acute intermittent porphyria: clinical and selected research aspects.
Acute intermittent porphyria is an inborn error of metabolism characterized by the excretion of excess porphyrin precursors… 
Highly Cited
1975
Highly Cited
1975
Biosynthesis of delta-aminolevulinic acid from the intact carbon skeleton of glutamic acid in greening barley.
The customary route in animals and bacteria for delta-aminolevulinic acid biosynthesis is from glycine and succinyl CoA… 
Highly Cited
1973
Highly Cited
1973
Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship.
2,3,7,8-Tetrachlorodibenzo-p-dioxin, an extremely potent toxin and teratogen formed during the commercial synthesis of the… 
Highly Cited
1966
Highly Cited
1966
The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals.
Highly Cited
1966
Highly Cited
1966
Delta-aminolevulinic acid synthetase. II. Induction in rat liver.
Abstract Administration of allylisopropylacetamide to rats causes a marked increase in the hepatic ribonucleic acid-dependent… 
Highly Cited
1966
Highly Cited
1966
Delta-aminolevulinic acid synthetase. I. Studies in liver homogenates.
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