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5-Aminolevulinate synthase
Known as:
Aminolevulinic Acid Synthetase
, Synthetase, 5-Aminolevulinate
, delta Aminolevulinate Synthase
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An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta…
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National Institutes of Health
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Related topics
Related topics
12 relations
5-aminolevulinate synthase activity
ALAS1 gene
In Blood
Process of secretion
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Narrower (2)
ALAS2 protein, human
Protoporphyria, Erythropoietic, X-Linked Dominant
Broader (1)
Acyltransferase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Exercise-induced Mitochondrial Biogenesis Begins before the Increase in Muscle PGC-1α Expression*
D. Wright
,
Dong‐Ho Han
,
P. García-Rovés
,
P. Geiger
,
T. Jones
,
J. Holloszy
Journal of Biological Chemistry
2007
Corpus ID: 550821
Exercise results in rapid increases in expression of the transcription coactivator peroxisome proliferator-activated receptor…
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Highly Cited
1995
Highly Cited
1995
Heme binds to a short sequence that serves a regulatory function in diverse proteins.
L. Zhang
,
L. Guarente
EMBO Journal
1995
Corpus ID: 36435113
Heme is a prosthetic group for numerous enzymes, cytochromes and globins, and it binds tightly, sometimes covalently, to these…
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Highly Cited
1995
Highly Cited
1995
Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis (*)
Young-Myeong Kim
,
H. Bergonia
,
C. Müller
,
B. Pitt
,
W. Watkins
,
J. Lancaster
Journal of Biological Chemistry
1995
Corpus ID: 25249371
We report here that, like nonheme iron, protein-bound intracellular heme iron is also a target for destruction by endogenously…
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Highly Cited
1993
Highly Cited
1993
Regulation by heme of mitochondrial protein transport through a conserved amino acid motif.
J. Lathrop
,
M. Timko
Science
1993
Corpus ID: 11660316
A conserved motif, termed the heme regulatory motif (HRM), was identified in the presequences of the erythroid delta…
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Highly Cited
1991
Highly Cited
1991
Human erythroid 5‐aminolevulinate synthase: promoter analysis and identification of an iron‐responsive element in the mRNA.
T. C. Cox
,
M. Bawden
,
A. Martín
,
B. May
EMBO Journal
1991
Corpus ID: 39513620
5‐Aminolevulinate synthase (ALAS) catalyzes the first step of the heme biosynthetic pathway. cDNA clones for the human erythroid…
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Highly Cited
1982
Highly Cited
1982
Heme biosynthesis in Rhizobium. Identification of a cloned gene coding for delta-aminolevulinic acid synthetase from Rhizobium meliloti.
S. Leong
,
G. Ditta
,
D. Helinski
Journal of Biological Chemistry
1982
Corpus ID: 21955217
Highly Cited
1966
Highly Cited
1966
The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals.
S. Granick
Journal of Biological Chemistry
1966
Corpus ID: 20808677
Highly Cited
1966
Highly Cited
1966
Delta-aminolevulinic acid synthetase. II. Induction in rat liver.
H. Marver
,
A. Collins
,
D. Tschudy
,
Miloslav (Mila). Rechcigl
Journal of Biological Chemistry
1966
Corpus ID: 20143273
Abstract Administration of allylisopropylacetamide to rats causes a marked increase in the hepatic ribonucleic acid-dependent…
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Highly Cited
1966
Highly Cited
1966
Delta-aminolevulinic acid synthetase. I. Studies in liver homogenates.
H. Marver
,
D. Tschudy
,
M. Perlroth
,
A. Collins
Journal of Biological Chemistry
1966
Corpus ID: 29531695
Highly Cited
1963
Highly Cited
1963
Increase in activity of alpha-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3,5-dicarbethoxy-1,4-dihydrocollidine.
S. Granick
,
G. Urata
Journal of Biological Chemistry
1963
Corpus ID: 39993986
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