5'-guanylylmethylenebisphosphonate

Known as: guanyl-5'-ylmethylenediphosphonate, GMP-PCP, 5'-guanylylmethylenediphosphonate 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antiviral AgentsGuanosine Triphosphate
analogs & derivatives

Papers overview

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Highly Cited
2015
Highly Cited
2015
Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins
Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by microtubule-associated proteins, including the… Expand
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Highly Cited
2014
Highly Cited
2014
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
Dynamic instability, the stochastic switching between growth and shrinkage, is essential for microtubule function. This behavior… Expand
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2012
2012
SulA inhibits assembly of FtsZ by a simple sequestration mechanism.
We have investigated the inhibition by SulA of the assembly of Escherichia coli FtsZ. Using quantitative GTPase and fluorescence… Expand
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Highly Cited
2011
Highly Cited
2011
A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke
The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific… Expand
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Highly Cited
2011
Highly Cited
2011
Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport
Polarized transport in neurons is fundamental for the formation of neuronal circuitry. A motor domain-containing truncated KIF5… Expand
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Highly Cited
2009
Highly Cited
2009
Microtubule plus-end tracking by CLIP-170 requires EB1.
Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening… Expand
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Highly Cited
2005
Highly Cited
2005
Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly
The atomic structure of tubulin in a polymerized, straight protofilament is clearly distinct from that in a curved conformation… Expand
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Highly Cited
2000
Highly Cited
2000
Straight and curved conformations of FtsZ are regulated by GTP hydrolysis.
FtsZ assembles in vitro into protofilaments that can adopt two conformations-the straight conformation, which can assemble… Expand
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Highly Cited
1992
Highly Cited
1992
Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.
The role of GTP hydrolysis in microtubule dynamics has been reinvestigated using an analogue of GTP, guanylyl-(alpha, beta… Expand
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Highly Cited
1988
Highly Cited
1988
Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues
The role of a guanine nucleotide-binding protein (Gk) in the coupling between muscarinic receptor activation and opening of an… Expand
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