Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

5'-guanylylmethylenebisphosphonate

Known as: guanyl-5'-ylmethylenediphosphonate, GMP-PCP, 5'-guanylylmethylenediphosphonate 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antiviral AgentsGuanosine Triphosphate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins
Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by microtubule-associated proteins, including the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2014
Highly Cited
2014
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
Dynamic instability, the stochastic switching between growth and shrinkage, is essential for microtubule function. This behavior… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2012
Highly Cited
2012
SulA inhibits assembly of FtsZ by a simple sequestration mechanism.
We have investigated the inhibition by SulA of the assembly of Escherichia coli FtsZ. Using quantitative GTPase and fluorescence… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke
The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport
The high affinity of KIF5 for microtubules rich in GTP-tubulin results in polarized motor protein accumulation at axonal tips in… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Microtubule plus-end tracking by CLIP-170 requires EB1
Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening… Expand
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly
The atomic structure of tubulin in a polymerized, straight protofilament is clearly distinct from that in a curved conformation… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Straight and curved conformations of FtsZ are regulated by GTP hydrolysis.
FtsZ assembles in vitro into protofilaments that can adopt two conformations-the straight conformation, which can assemble… Expand
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.
The role of GTP hydrolysis in microtubule dynamics has been reinvestigated using an analogue of GTP, guanylyl-(alpha, beta… Expand
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues
The role of a guanine nucleotide-binding protein (Gk) in the coupling between muscarinic receptor activation and opening of an… Expand
  • figure 2
  • figure 3
  • figure 5
  • figure 6
  • figure 8
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE