M. Marletta

Publications329
h-index87
Citations28,926
Highly Influential Citations941
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Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa.
TLDR
Cellobiose dehydrogenases and proteins related to the polysaccharide monooxygenases described here are found throughout both ascomycete and basidiomycete fungi, suggesting that this model for oxidative cellulose degradation may be widespread throughout the fungal kingdom.
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Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
TLDR
It is shown that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5–12% oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments.
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Nitric oxide synthase structure and mechanism.
  • M. Marletta
  • Medicine, Chemistry
    The Journal of biological chemistry
  • 15 June 1993
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Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases
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Potent and selective inhibition of neuronal nitric oxide synthase by N(ω)-propyl-L-arginine
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Structure and regulation of soluble guanylate cyclase.
TLDR
This review summarizes the current understanding of sGC structure and regulation as well as recent developments in NO signaling to aid therapeutic intervention in diseases involving the NO/cGMP-signaling pathway.
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Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.
TLDR
Results indicate that T cell lymphokines and IFN-gamma are powerful modulators of macrophage nitrite/nitrate synthesis during BCG infection and in vitro, and nitrite / nitrate synthesis appears to be common property of both primed and fully activated macrophages.
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Nitric oxide synthase: Aspects concerning structure and catalysis
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Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.
TLDR
L-Arginine is required for the activation of macrophages to the bactericidal/tumoricidal state and suggests that nitric oxide is serving as an intracellular signal for this activation process in a manner similar to that very recently observed in endothelial cells, where nitrics oxide leads to vascular smooth muscle relaxation.
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Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.
TLDR
GC/MS experiments using L-[guanido-15N2]arginine established that the NO2-/NO3- and the nitrosyl group of N-nitrosomorpholine were derived exclusively from one or both of the terminal guanido nitrogens of arginine.
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