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Prokaryotic origin of the actin cytoskeleton
It was thought until recently that bacteria lack the actin or tubulin filament networks that organize eukaryotic cytoplasm. However, we show here that the bacterial MreB protein assembles into… Expand
Tubulin and FtsZ form a distinct family of GTPases
Tubulin and FtsZ share a common fold of two domains connected by a central helix. Structure-based sequence alignment shows that common residues localize in the nucleotide-binding site and a region… Expand
Crystal structure of the bacterial cell-division protein FtsZ
Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells,. During septation, FtsZ, a protein of relative… Expand
Three-dimensional structure determination by electron microscopy of two-dimensional crystals.
F‐actin‐like filaments formed by plasmid segregation protein ParM
- F. van den Ent, J. Møller-Jensen, L. Amos, K. Gerdes, J. Löwe
- Biology, Medicine
- The EMBO journal
- 16 December 2002
It was the general belief that DNA partitioning in prokaryotes is independent of a cytoskeletal structure, which in eukaryotic cells is indispensable for DNA segregation. Recently, however,… Expand
Arrangement of subunits in flagellar microtubules.
Electron micrographs of outer doublet tubules from flagella have been analysed by methods which make use of the computed diffraction patterns of electron-microscope images. Analysis of singlet… Expand
Structure of a Bacterial Dynamin-like Protein Lipid Tube Provides a Mechanism For Assembly and Membrane Curving
Summary Proteins of the dynamin superfamily mediate membrane fission, fusion, and restructuring events by polymerizing upon lipid bilayers and forcing regions of high curvature. In this work, we show… Expand
Three Dimensional Reconstructions of Spherical Viruses by Fourier Synthesis from Electron Micrographs
- R. A. Crowther, L. Amos, J. Finch, D. J. D. Rosier, A. Klug
- Materials Science, Medicine
- 1 May 1970
Methods are developed for computing three dimensional density maps from transmission electron micrographs using Fourier transforms. The reconstructions objectively combine data from several different… Expand
Microtubules and maps.
Microtubules are very dynamic polymers whose assembly and disassembly is determined by whether their heterodimeric tubulin subunits are in a straight or curved conformation. Curvature is introduced… Expand
Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
The tau family of microtubule‐associated proteins has a microtubule‐binding domain which includes three or four conserved sequence repeats. Pelleting assays show that when tubulin and tau are co‐… Expand