4-hydroxyestrone

Known as: 4-OHE1, 4-OHE(1), 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one 
A metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 4 by cytochrome P450 (CYP… (More)
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP… (More)
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Highly Cited
2001
Highly Cited
2001
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… (More)
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Review
2000
Review
2000
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to… (More)
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2000
2000
Recent data indicate that the catechol estrogen, 2-hydroxyestrone (2-OHE(1)), has no effect on any target tissue including bone… (More)
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2000
2000
Estrogen replacement therapy has been correlated with an increased risk of developing breast or endometrial cancer. 4… (More)
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1998
1998
Catechol estrogen quinones (CE-Q) have been implicated as ultimate carcinogenic metabolites in estrogen-induced carcinogenesis… (More)
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Highly Cited
1998
Highly Cited
1998
Isoflavones and lignans are soy phytoestrogens that have been suggested to be anticarcinogenic. The mechanisms by which they… (More)
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Highly Cited
1994
Highly Cited
1994
The human cytosolic sulfotransferases (STs), dehydroepiandrosterone sulfotransferase (DHEA-ST) and the phenol-sulfating form of… (More)
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Review
1993
Review
1993
Endogenous and exogenous estrogens undergo extensive oxidative metabolism by specific cytochrome P450 enzymes. Certain drugs and… (More)
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1992
1992
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… (More)
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