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4-hydroxyestrone

Known as: 4-OHE1, 4-OHE(1), 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one 
A metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 4 by cytochrome P450 (CYP… 
National Institutes of Health

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Hydroxyestrones

Papers overview

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2010
2010
Simultaneous determination of eight estrogens and their metabolites in serum using liquid chromatography with electrochemical detection.
2001
2001
Analysis of potential biomarkers of estrogen-initiated cancer in the urine of Syrian golden hamsters treated with 4-hydroxyestradiol.
Estrone (E1) and 17beta-estradiol (E2) are metabolized to catechol estrogens (CE), which may be oxidized to semiquinones and… 
1998
1998
Metabolic activation and formation of DNA adducts of hexestrol, a synthetic nonsteroidal carcinogenic estrogen.
Hexestrol (HES), a synthetic nonsteroidal estrogen, is carcinogenic in Syrian golden hamsters. The major metabolite of HES is its… 
1998
1998
Covalent binding of catechol estrogens to glutathione catalyzed by horseradish peroxidase, lactoperoxidase, or rat liver microsomes.
Oxidation of catechol estrogens (CE) leads to the reactive electrophilic CE quinones. Reaction of CE-3,4-quinones with DNA has… 
1997
1997
Estrogen-nucleic acid adducts: reaction of 3,4-estrone-o-quinone radical anion with deoxyribonucleosides.
Metabolic activation of estradiol leading to the formation of catechol estrogens is believed to be a prerequisite for its… 
Highly Cited
1994
Highly Cited
1994
Conversion of estrone to 2- and 4-hydroxyestrone by hamster kidney and liver microsomes: implications for the mechanism of estrogen-induced carcinogenesis.
As part of an ongoing investigation of the role of metabolic activation of estrogens in the genesis of cancers such as estrogen… 
Highly Cited
1992
Highly Cited
1992
Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens.
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… 
Highly Cited
1979
Highly Cited
1979
Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion.
The biological activity of a series of natural catechol estrogens was examined under conditions of continuous administration. 2… 
Highly Cited
1976
Highly Cited
1976
Convenient large scale preparation of catechol estrogens
Highly Cited
1973
Highly Cited
1973
A simple chemical method for the synthesis of catechol estrogens.
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