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4-hydroxyestrone

Known as: 4-OHE1, 4-OHE(1), 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one 
A metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 4 by cytochrome P450 (CYP… Expand
National Institutes of Health

Papers overview

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2013
2013
Although estrogen and the enzymes responsible for its metabolism have been detected within the lung, the ability of this tissue… Expand
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Highly Cited
2003
Highly Cited
2003
We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP… Expand
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Highly Cited
2001
Highly Cited
2001
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… Expand
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Review
2000
Review
2000
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to… Expand
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Highly Cited
1999
Highly Cited
1999
Considering the physiologic importance of the steroid response, which is regulated in part by steroid levels in a given tissue… Expand
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Highly Cited
1998
Highly Cited
1998
Catechol estrogen quinones (CE-Q) have been implicated as ultimate carcinogenic metabolites in estrogen-induced carcinogenesis… Expand
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Highly Cited
1998
Highly Cited
1998
Isoflavones and lignans are soy phytoestrogens that have been suggested to be anticarcinogenic. The mechanisms by which they… Expand
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Highly Cited
1995
Highly Cited
1995
Free radical generation by metabolic redox cycling between catechol estrogens and their quinones and subsequent hydroxyl radical… Expand
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Review
1993
Review
1993
Endogenous and exogenous estrogens undergo extensive oxidative metabolism by specific cytochrome P450 enzymes. Certain drugs and… Expand
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Highly Cited
1992
Highly Cited
1992
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… Expand
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